Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979697395> ?p ?o ?g. }
- W1979697395 abstract "In Caenorhabdtis elegans, Ced-3, Ced-4, and Ced-9 are components of a cell suicide program. Ced-4 facilitates the proteolytic activation of the caspase, Ced-3, while Ced-9 opposes Ced-3/Ced-4 killing. To examine the interactions among these proteins they were expressed in Saccharomyces cerevisiae. Ced-3 and Ced-4 were lethal when expressed alone, revealing an intrinsic Ced-4 killing activity. Coexpression of Ced-9 blocked Ced-3- and Ced-4-induced killing, showing Ced-9 can independently antagonize the action of both proteins. Ced-3- but not Ced-4-toxicity was attenuated by coexpression of the caspase inhibitors, CrmA and p35. Thus, besides its Ced-3- and Ced-9-dependent action in C. elegans, Ced-4 has an additional Ced-9-dependent, Ced-3-independent killing mechanism in yeast. Two-hybrid analysis confirmed that Ced-4 formed heteromers with Ced-9. In addition, Ced-4 formed homomers and mutation of its nucleoside triphosphate binding motif eliminated both homomerization and cell killing. We suggest the caspase-independent lethality of Ced-4 in yeast is mediated by a Ced-4 homomer." @default.
- W1979697395 created "2016-06-24" @default.
- W1979697395 creator A5013343091 @default.
- W1979697395 creator A5059155537 @default.
- W1979697395 creator A5086574336 @default.
- W1979697395 date "1999-07-01" @default.
- W1979697395 modified "2023-09-26" @default.
- W1979697395 title "Oligomerized Ced-4 Kills Budding Yeast through a Caspase-Independent Mechanism" @default.
- W1979697395 cites W1540875193 @default.
- W1979697395 cites W1612820086 @default.
- W1979697395 cites W1624001120 @default.
- W1979697395 cites W1969331809 @default.
- W1979697395 cites W1975670576 @default.
- W1979697395 cites W1976312800 @default.
- W1979697395 cites W1979842763 @default.
- W1979697395 cites W1980037437 @default.
- W1979697395 cites W1986388339 @default.
- W1979697395 cites W1987785848 @default.
- W1979697395 cites W2000352412 @default.
- W1979697395 cites W2004487226 @default.
- W1979697395 cites W2008348103 @default.
- W1979697395 cites W2013319326 @default.
- W1979697395 cites W2017708875 @default.
- W1979697395 cites W2021943787 @default.
- W1979697395 cites W2024256697 @default.
- W1979697395 cites W2025404996 @default.
- W1979697395 cites W2025426978 @default.
- W1979697395 cites W2026152653 @default.
- W1979697395 cites W2029247738 @default.
- W1979697395 cites W2033596981 @default.
- W1979697395 cites W2039355845 @default.
- W1979697395 cites W2041090790 @default.
- W1979697395 cites W2043651078 @default.
- W1979697395 cites W2045850215 @default.
- W1979697395 cites W2049873418 @default.
- W1979697395 cites W2051219590 @default.
- W1979697395 cites W2054681435 @default.
- W1979697395 cites W2057833513 @default.
- W1979697395 cites W2059666350 @default.
- W1979697395 cites W2064714878 @default.
- W1979697395 cites W2068240610 @default.
- W1979697395 cites W2068637026 @default.
- W1979697395 cites W2071046730 @default.
- W1979697395 cites W2077987011 @default.
- W1979697395 cites W2079513929 @default.
- W1979697395 cites W2082624222 @default.
- W1979697395 cites W2083560313 @default.
- W1979697395 cites W2085601531 @default.
- W1979697395 cites W2092548393 @default.
- W1979697395 cites W2092971310 @default.
- W1979697395 cites W2119683782 @default.
- W1979697395 cites W2120939161 @default.
- W1979697395 cites W2130490261 @default.
- W1979697395 cites W2134205510 @default.
- W1979697395 cites W2140482135 @default.
- W1979697395 cites W2140951631 @default.
- W1979697395 cites W2143772496 @default.
- W1979697395 cites W2144701362 @default.
- W1979697395 doi "https://doi.org/10.1006/bbrc.1999.0982" @default.
- W1979697395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10403845" @default.
- W1979697395 hasPublicationYear "1999" @default.
- W1979697395 type Work @default.
- W1979697395 sameAs 1979697395 @default.
- W1979697395 citedByCount "16" @default.
- W1979697395 countsByYear W19796973952016 @default.
- W1979697395 crossrefType "journal-article" @default.
- W1979697395 hasAuthorship W1979697395A5013343091 @default.
- W1979697395 hasAuthorship W1979697395A5059155537 @default.
- W1979697395 hasAuthorship W1979697395A5086574336 @default.
- W1979697395 hasConcept C153911025 @default.
- W1979697395 hasConcept C185592680 @default.
- W1979697395 hasConcept C190283241 @default.
- W1979697395 hasConcept C202751555 @default.
- W1979697395 hasConcept C2776120743 @default.
- W1979697395 hasConcept C2777576037 @default.
- W1979697395 hasConcept C2779222958 @default.
- W1979697395 hasConcept C31573885 @default.
- W1979697395 hasConcept C55493867 @default.
- W1979697395 hasConcept C86803240 @default.
- W1979697395 hasConcept C95444343 @default.
- W1979697395 hasConcept C98424977 @default.
- W1979697395 hasConceptScore W1979697395C153911025 @default.
- W1979697395 hasConceptScore W1979697395C185592680 @default.
- W1979697395 hasConceptScore W1979697395C190283241 @default.
- W1979697395 hasConceptScore W1979697395C202751555 @default.
- W1979697395 hasConceptScore W1979697395C2776120743 @default.
- W1979697395 hasConceptScore W1979697395C2777576037 @default.
- W1979697395 hasConceptScore W1979697395C2779222958 @default.
- W1979697395 hasConceptScore W1979697395C31573885 @default.
- W1979697395 hasConceptScore W1979697395C55493867 @default.
- W1979697395 hasConceptScore W1979697395C86803240 @default.
- W1979697395 hasConceptScore W1979697395C95444343 @default.
- W1979697395 hasConceptScore W1979697395C98424977 @default.
- W1979697395 hasLocation W19796973951 @default.
- W1979697395 hasLocation W19796973952 @default.
- W1979697395 hasOpenAccess W1979697395 @default.
- W1979697395 hasPrimaryLocation W19796973951 @default.
- W1979697395 hasRelatedWork W1505515480 @default.
- W1979697395 hasRelatedWork W2050374206 @default.
- W1979697395 hasRelatedWork W2067820742 @default.