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- W1979700577 abstract "Summary At the same time as biophysical and omics approaches are drilling deeper into the molecular details of platelets and other blood cells, as well as their receptors and mechanisms of regulation, there is also an increasing awareness of the functional overlap between human vascular systems. Together, these studies are redefining the intricate networks linking haemostasis and thrombosis with inflammation, infectious disease, cancer/metastasis and other vascular pathophysiology. The focus of this state‐of‐the‐art review is some of the newer advances relevant to primary haemostasis. Of particular interest, platelet‐specific primary adhesion‐signalling receptors and associated activation pathways control platelet function in flowing blood and provide molecular links to other systems. Platelet glycoprotein ( GP )Ibα of the GPI b‐ IX ‐ V complex and GPVI not only initiate platelet aggregation and thrombus formation by primary interactions with von Willebrand factor and collagen, respectively, but are also involved in coagulation, leucocyte engagement, bacterial or viral interactions, and are relevant as potential risk markers in a range of human diseases. Understanding these systems in unprecedented detail promises significant advances in evaluation of individual risk, in new diagnostic or therapeutic possibilities and in monitoring the response to drugs or other treatment." @default.
- W1979700577 created "2016-06-24" @default.
- W1979700577 creator A5007144926 @default.
- W1979700577 creator A5055483790 @default.
- W1979700577 creator A5065834493 @default.
- W1979700577 date "2014-04-25" @default.
- W1979700577 modified "2023-10-06" @default.
- W1979700577 title "Primary haemostasis: newer insights" @default.
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- W1979700577 doi "https://doi.org/10.1111/hae.12427" @default.
- W1979700577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24762270" @default.
- W1979700577 hasPublicationYear "2014" @default.
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