Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979701034> ?p ?o ?g. }
- W1979701034 endingPage "581" @default.
- W1979701034 startingPage "572" @default.
- W1979701034 abstract "Hyperhomocysteinemia is a risk factor for vascular and neuronal lesions often observed with concomitant high levels of homocysteic acid. In contrast to homocysteine, homocysteic acid induces calcium influx into neurons, with characteristics of an excitotoxic glutamatergic agonist at elevated concentrations. On the molecular level this is correlated to fast modifications of proteins (phosphorylation and proteolysis). Within the homocysteic acid induced molecular signature we focused in more detail on phosphorylation of two proteins implicated as risk factors in schizophrenia and neurodegeneration: Dihydropyrimidinase related protein and 14−3−3 protein isoforms. Among the identified proteins there are known chaperones and oxidative metabolism enzymes, but a few are new in context of neuronal stress: Lasp-1, a vitamin D associated factor and an expressed sequence with features of a Rho GDP dissociation inhibitor. Moreover, we detect a specific proteolytic processing of heat shock protein 70 and proteindisulfide isomerase, which is abolished by vitamins (folic acid, vitamin B12, and vitamin B6), which also decrease elevated intracellular calcium levels induced by homocysteic acid. Keywords: differential proteomics • dihydropyrimidinase related protein • homocysteic acid • neuronal stress • phosphorylation • rho • lasp-1 • vitamin D associated factor • heat shock protein 70 • protein disulfide isomerase • embryonic stem cells • calcium" @default.
- W1979701034 created "2016-06-24" @default.
- W1979701034 creator A5014401117 @default.
- W1979701034 creator A5016562697 @default.
- W1979701034 creator A5030177102 @default.
- W1979701034 creator A5031279800 @default.
- W1979701034 creator A5036602289 @default.
- W1979701034 creator A5055823331 @default.
- W1979701034 creator A5059028860 @default.
- W1979701034 creator A5060735886 @default.
- W1979701034 creator A5068544571 @default.
- W1979701034 creator A5080501190 @default.
- W1979701034 creator A5085344076 @default.
- W1979701034 date "2004-03-25" @default.
- W1979701034 modified "2023-10-16" @default.
- W1979701034 title "Molecular Analysis of Homocysteic Acid-Induced Neuronal Stress" @default.
- W1979701034 cites W1506485465 @default.
- W1979701034 cites W1513601545 @default.
- W1979701034 cites W1760583335 @default.
- W1979701034 cites W1963770237 @default.
- W1979701034 cites W1970244956 @default.
- W1979701034 cites W1971697017 @default.
- W1979701034 cites W1974110822 @default.
- W1979701034 cites W1975336540 @default.
- W1979701034 cites W1980823360 @default.
- W1979701034 cites W1986547692 @default.
- W1979701034 cites W1996818295 @default.
- W1979701034 cites W1999349182 @default.
- W1979701034 cites W2007361649 @default.
- W1979701034 cites W2010465386 @default.
- W1979701034 cites W2010686273 @default.
- W1979701034 cites W2014217419 @default.
- W1979701034 cites W2015034528 @default.
- W1979701034 cites W2016597855 @default.
- W1979701034 cites W2020161289 @default.
- W1979701034 cites W2020357295 @default.
- W1979701034 cites W2021494076 @default.
- W1979701034 cites W2023827302 @default.
- W1979701034 cites W2024465918 @default.
- W1979701034 cites W2025407633 @default.
- W1979701034 cites W2027246053 @default.
- W1979701034 cites W2027397876 @default.
- W1979701034 cites W2059196092 @default.
- W1979701034 cites W2059691969 @default.
- W1979701034 cites W2072529095 @default.
- W1979701034 cites W2078594804 @default.
- W1979701034 cites W2081260040 @default.
- W1979701034 cites W2082480208 @default.
- W1979701034 cites W2088483796 @default.
- W1979701034 cites W2089346967 @default.
- W1979701034 cites W2092071477 @default.
- W1979701034 cites W2092179638 @default.
- W1979701034 cites W2106814023 @default.
- W1979701034 cites W2114471378 @default.
- W1979701034 cites W2118015493 @default.
- W1979701034 cites W2118846412 @default.
- W1979701034 cites W2122772601 @default.
- W1979701034 cites W2125862106 @default.
- W1979701034 cites W2131954858 @default.
- W1979701034 cites W2132457979 @default.
- W1979701034 cites W2141260882 @default.
- W1979701034 cites W2144708173 @default.
- W1979701034 cites W2157349345 @default.
- W1979701034 cites W2159922182 @default.
- W1979701034 cites W2279053739 @default.
- W1979701034 cites W2404521408 @default.
- W1979701034 cites W4249978892 @default.
- W1979701034 doi "https://doi.org/10.1021/pr034115o" @default.
- W1979701034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15253439" @default.
- W1979701034 hasPublicationYear "2004" @default.
- W1979701034 type Work @default.
- W1979701034 sameAs 1979701034 @default.
- W1979701034 citedByCount "27" @default.
- W1979701034 countsByYear W19797010342012 @default.
- W1979701034 countsByYear W19797010342013 @default.
- W1979701034 countsByYear W19797010342014 @default.
- W1979701034 countsByYear W19797010342015 @default.
- W1979701034 countsByYear W19797010342020 @default.
- W1979701034 countsByYear W19797010342021 @default.
- W1979701034 crossrefType "journal-article" @default.
- W1979701034 hasAuthorship W1979701034A5014401117 @default.
- W1979701034 hasAuthorship W1979701034A5016562697 @default.
- W1979701034 hasAuthorship W1979701034A5030177102 @default.
- W1979701034 hasAuthorship W1979701034A5031279800 @default.
- W1979701034 hasAuthorship W1979701034A5036602289 @default.
- W1979701034 hasAuthorship W1979701034A5055823331 @default.
- W1979701034 hasAuthorship W1979701034A5059028860 @default.
- W1979701034 hasAuthorship W1979701034A5060735886 @default.
- W1979701034 hasAuthorship W1979701034A5068544571 @default.
- W1979701034 hasAuthorship W1979701034A5080501190 @default.
- W1979701034 hasAuthorship W1979701034A5085344076 @default.
- W1979701034 hasConcept C126322002 @default.
- W1979701034 hasConcept C185592680 @default.
- W1979701034 hasConcept C2776925932 @default.
- W1979701034 hasConcept C2779134260 @default.
- W1979701034 hasConcept C55493867 @default.
- W1979701034 hasConcept C71924100 @default.
- W1979701034 hasConcept C86803240 @default.