Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979704125> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1979704125 endingPage "3059" @default.
- W1979704125 startingPage "3051" @default.
- W1979704125 abstract "We used a combination of optical and calorimetric techniques to investigate the incorporation of deoxythymidine → deoxyuridine (dT → dU) substitutions in the duplex and third strand of the parallel intramolecular triplex d(A7C5T7C5T7) (ATT). UV and differential scanning calorimetry melting experiments show that the incorporation of two substitutions yielded triplexes with lower thermal stability and lower unfolding enthalpies. The enthalpies decrease with an increase in salt concentration, indirectly yielding a heat capacity effect, and the magnitude of this effect was lower for the substituted triplexes. The combined results indicate that the destabilizing effect is due to a decrease in the level of stacking interactions. Furthermore, the minor groove ligand netropsin binds to the minor groove and to the hydrophobic groove, created by the double chain of thymine methyl groups in the major groove of these triplexes. Binding of netropsin to the minor groove yielded thermodynamic profiles similar to that of a DNA duplex with a similar sequence. However, and relative to ATT, binding of netropsin to the hydrophobic groove has a decreased binding affinity and lower binding enthalpy. This shows that the presence of uridine bases disrupts the hydrophobic groove and lowers its cooperativity toward ligand binding. The overall results suggest that the stabilizing effect of methyl groups may arise from the combination of both hydrophobic and electronic effects." @default.
- W1979704125 created "2016-06-24" @default.
- W1979704125 creator A5005349624 @default.
- W1979704125 creator A5012489838 @default.
- W1979704125 creator A5049941183 @default.
- W1979704125 creator A5063832447 @default.
- W1979704125 creator A5081378955 @default.
- W1979704125 date "2006-02-08" @default.
- W1979704125 modified "2023-09-27" @default.
- W1979704125 title "DNA Intramolecular Triplexes Containing dT → dU Substitutions: Unfolding Energetics and Ligand Binding" @default.
- W1979704125 cites W1495475575 @default.
- W1979704125 cites W1601240528 @default.
- W1979704125 cites W1967851567 @default.
- W1979704125 cites W2055222882 @default.
- W1979704125 cites W2079911307 @default.
- W1979704125 cites W2086598566 @default.
- W1979704125 cites W4210928033 @default.
- W1979704125 doi "https://doi.org/10.1021/bi052203b" @default.
- W1979704125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16503660" @default.
- W1979704125 hasPublicationYear "2006" @default.
- W1979704125 type Work @default.
- W1979704125 sameAs 1979704125 @default.
- W1979704125 citedByCount "16" @default.
- W1979704125 countsByYear W19797041252013 @default.
- W1979704125 countsByYear W19797041252014 @default.
- W1979704125 countsByYear W19797041252015 @default.
- W1979704125 countsByYear W19797041252016 @default.
- W1979704125 countsByYear W19797041252017 @default.
- W1979704125 countsByYear W19797041252018 @default.
- W1979704125 crossrefType "journal-article" @default.
- W1979704125 hasAuthorship W1979704125A5005349624 @default.
- W1979704125 hasAuthorship W1979704125A5012489838 @default.
- W1979704125 hasAuthorship W1979704125A5049941183 @default.
- W1979704125 hasAuthorship W1979704125A5063832447 @default.
- W1979704125 hasAuthorship W1979704125A5081378955 @default.
- W1979704125 hasConcept C107824862 @default.
- W1979704125 hasConcept C116569031 @default.
- W1979704125 hasConcept C121332964 @default.
- W1979704125 hasConcept C166014724 @default.
- W1979704125 hasConcept C170493617 @default.
- W1979704125 hasConcept C178790620 @default.
- W1979704125 hasConcept C185592680 @default.
- W1979704125 hasConcept C187250156 @default.
- W1979704125 hasConcept C2776858809 @default.
- W1979704125 hasConcept C2781063032 @default.
- W1979704125 hasConcept C3019303373 @default.
- W1979704125 hasConcept C3288061 @default.
- W1979704125 hasConcept C33347731 @default.
- W1979704125 hasConcept C552990157 @default.
- W1979704125 hasConcept C55493867 @default.
- W1979704125 hasConcept C71240020 @default.
- W1979704125 hasConcept C75079739 @default.
- W1979704125 hasConcept C8010536 @default.
- W1979704125 hasConcept C90260826 @default.
- W1979704125 hasConcept C97355855 @default.
- W1979704125 hasConcept C99611785 @default.
- W1979704125 hasConceptScore W1979704125C107824862 @default.
- W1979704125 hasConceptScore W1979704125C116569031 @default.
- W1979704125 hasConceptScore W1979704125C121332964 @default.
- W1979704125 hasConceptScore W1979704125C166014724 @default.
- W1979704125 hasConceptScore W1979704125C170493617 @default.
- W1979704125 hasConceptScore W1979704125C178790620 @default.
- W1979704125 hasConceptScore W1979704125C185592680 @default.
- W1979704125 hasConceptScore W1979704125C187250156 @default.
- W1979704125 hasConceptScore W1979704125C2776858809 @default.
- W1979704125 hasConceptScore W1979704125C2781063032 @default.
- W1979704125 hasConceptScore W1979704125C3019303373 @default.
- W1979704125 hasConceptScore W1979704125C3288061 @default.
- W1979704125 hasConceptScore W1979704125C33347731 @default.
- W1979704125 hasConceptScore W1979704125C552990157 @default.
- W1979704125 hasConceptScore W1979704125C55493867 @default.
- W1979704125 hasConceptScore W1979704125C71240020 @default.
- W1979704125 hasConceptScore W1979704125C75079739 @default.
- W1979704125 hasConceptScore W1979704125C8010536 @default.
- W1979704125 hasConceptScore W1979704125C90260826 @default.
- W1979704125 hasConceptScore W1979704125C97355855 @default.
- W1979704125 hasConceptScore W1979704125C99611785 @default.
- W1979704125 hasIssue "9" @default.
- W1979704125 hasLocation W19797041251 @default.
- W1979704125 hasLocation W19797041252 @default.
- W1979704125 hasOpenAccess W1979704125 @default.
- W1979704125 hasPrimaryLocation W19797041251 @default.
- W1979704125 hasRelatedWork W1534300168 @default.
- W1979704125 hasRelatedWork W1979704125 @default.
- W1979704125 hasRelatedWork W2020563452 @default.
- W1979704125 hasRelatedWork W2066774912 @default.
- W1979704125 hasRelatedWork W2067882171 @default.
- W1979704125 hasRelatedWork W2076855871 @default.
- W1979704125 hasRelatedWork W2108321239 @default.
- W1979704125 hasRelatedWork W2149359092 @default.
- W1979704125 hasRelatedWork W3105859178 @default.
- W1979704125 hasRelatedWork W2552428624 @default.
- W1979704125 hasVolume "45" @default.
- W1979704125 isParatext "false" @default.
- W1979704125 isRetracted "false" @default.
- W1979704125 magId "1979704125" @default.
- W1979704125 workType "article" @default.