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• W1979711098 endingPage "462" @default.
• W1979711098 startingPage "462" @default.
• W1979711098 abstract "Multiple factors are involved in the etiology of cardiovascular disease (CVD). Pathological changes occur in a variety of cell types long before symptoms become apparent and diagnosis is made. Dysregulation of physiological functions are associated with the activation of immune cells, leading to local and finally systemic inflammation that is characterized by production of high levels of reactive oxygen species (ROS). Patients suffering from inflammatory diseases often present with diminished levels of antioxidants either due to insufficient dietary intake or, and even more likely, due to increased demand in situations of overwhelming ROS production by activated immune effector cells like macrophages. Antioxidants are suggested to beneficially interfere with diseases-related oxidative stress, however the interplay of endogenous and exogenous antioxidants with the overall redox system is complex. Moreover, molecular mechanisms underlying oxidative stress in CVD are not fully elucidated. Metabolic dybalances are suggested to play a major role in disease onset and progression. Several central signaling pathways involved in the regulation of immunological, metabolic and endothelial function are regulated in a redox-sensitive manner. During cellular immune response, interferon γ-dependent pathways are activated such as tryptophan breakdown by the enzyme indoleamine 2,3-dioxygenase (IDO) in monocyte-derived macrophages, fibroblasts, endothelial and epithelial cells. Neopterin, a marker of oxidative stress and immune activation is produced by GTP-cyclohydrolase I in macrophages and dendritic cells. Nitric oxide synthase (NOS) is induced in several cell types to generate nitric oxide (NO). NO, despite its low reactivity, is a potent antioxidant involved in the regulation of the vasomotor tone and of immunomodulatory signaling pathways. NO inhibits the expression and function of IDO. Function of NOS requires the cofactor tetrahydrobiopterin (BH4), which is produced in humans primarily by fibroblasts and endothelial cells. Highly toxic peroxynitrite (ONOO(-)) is formed solely in the presence of superoxide anion (O2 (-)). Neopterin and kynurenine to tryptophan ratio (Kyn/Trp), as an estimate of IDO enzyme activity, are robust markers of immune activation in vitro and in vivo. Both these diagnostic parameters are able to predict cardiovascular and overall mortality in patients at risk. Likewise, a significant association exists between increase of neopterin concentrations and Kyn/Trp ratio values and the lowering of plasma levels of vitamin-C, -E and -B. Vitamin-B deficiency is usually accompanied by increased plasma homoycsteine. Additional determination of NO metabolites, BH4 and plasma antioxidants in patients with CVD and related clinical settings can be helpful to improve the understanding of redox-regulation in health and disease and might provide a rationale for potential antioxidant therapies in CVD." @default.
• W1979711098 created "2016-06-24" @default.
• W1979711098 creator A5028943756 @default.
• W1979711098 creator A5032201189 @default.
• W1979711098 creator A5054772233 @default.
• W1979711098 creator A5081156604 @default.
• W1979711098 date "2014-01-01" @default.
• W1979711098 modified "2023-10-18" @default.
• W1979711098 title "Antioxidants, inflammation and cardiovascular disease" @default.
• W1979711098 cites W12245359 @default.
• W1979711098 cites W1479698819 @default.
• W1979711098 cites W1498611516 @default.
• W1979711098 cites W1580718840 @default.
• W1979711098 cites W1598081091 @default.
• W1979711098 cites W1645656667 @default.
• W1979711098 cites W1650863056 @default.
• W1979711098 cites W1674491527 @default.
• W1979711098 cites W1834981029 @default.
• W1979711098 cites W1925988920 @default.
• W1979711098 cites W1942388905 @default.
• W1979711098 cites W1963621262 @default.
• W1979711098 cites W1963913523 @default.
• W1979711098 cites W1964064254 @default.
• W1979711098 cites W1964639738 @default.
• W1979711098 cites W1965941423 @default.
• W1979711098 cites W1966656379 @default.
• W1979711098 cites W1966916765 @default.
• W1979711098 cites W1967053946 @default.
• W1979711098 cites W1968938434 @default.
• W1979711098 cites W1972483153 @default.
• W1979711098 cites W1973361612 @default.
• W1979711098 cites W1974130599 @default.
• W1979711098 cites W1975881881 @default.
• W1979711098 cites W1976595290 @default.
• W1979711098 cites W1976616659 @default.
• W1979711098 cites W1977328687 @default.
• W1979711098 cites W1977386338 @default.
• W1979711098 cites W1978299842 @default.
• W1979711098 cites W1979296983 @default.
• W1979711098 cites W1980458823 @default.
• W1979711098 cites W1981333727 @default.
• W1979711098 cites W1985046186 @default.
• W1979711098 cites W1986868330 @default.
• W1979711098 cites W1987484641 @default.
• W1979711098 cites W1987888941 @default.
• W1979711098 cites W1990594604 @default.
• W1979711098 cites W1993952575 @default.
• W1979711098 cites W1994437526 @default.
• W1979711098 cites W1995009104 @default.
• W1979711098 cites W1995091595 @default.
• W1979711098 cites W1995118720 @default.
• W1979711098 cites W1995266055 @default.
• W1979711098 cites W1996540389 @default.
• W1979711098 cites W1997380101 @default.
• W1979711098 cites W1998222575 @default.
• W1979711098 cites W2000054651 @default.
• W1979711098 cites W2000386430 @default.
• W1979711098 cites W2001047636 @default.
• W1979711098 cites W2002192155 @default.
• W1979711098 cites W2004681444 @default.
• W1979711098 cites W2007752173 @default.
• W1979711098 cites W2007756733 @default.
• W1979711098 cites W2008228060 @default.
• W1979711098 cites W2008331846 @default.
• W1979711098 cites W2012836981 @default.
• W1979711098 cites W2013144391 @default.
• W1979711098 cites W2014950417 @default.
• W1979711098 cites W2015700821 @default.
• W1979711098 cites W2016263229 @default.
• W1979711098 cites W2019814232 @default.
• W1979711098 cites W2021010648 @default.
• W1979711098 cites W2024679196 @default.
• W1979711098 cites W2026682916 @default.
• W1979711098 cites W2026759435 @default.
• W1979711098 cites W2026803942 @default.
• W1979711098 cites W2029249245 @default.
• W1979711098 cites W2031084334 @default.
• W1979711098 cites W2031579146 @default.
• W1979711098 cites W2033375332 @default.
• W1979711098 cites W2033896075 @default.
• W1979711098 cites W2034044797 @default.
• W1979711098 cites W2036670100 @default.
• W1979711098 cites W2037289141 @default.
• W1979711098 cites W2038012068 @default.
• W1979711098 cites W2038539286 @default.
• W1979711098 cites W2038709676 @default.
• W1979711098 cites W2046991199 @default.
• W1979711098 cites W2048556479 @default.
• W1979711098 cites W2050548878 @default.
• W1979711098 cites W2051701096 @default.
• W1979711098 cites W2051785336 @default.
• W1979711098 cites W20525028 @default.
• W1979711098 cites W2054119323 @default.
• W1979711098 cites W2055228598 @default.
• W1979711098 cites W2055823448 @default.
• W1979711098 cites W2057835664 @default.
• W1979711098 cites W2057988490 @default.
• W1979711098 cites W2059884861 @default.

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