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- W1979730205 abstract "Abstract The feasibility of atmospheric pressure desorption/ionization on silicon mass spectrometry (AP‐DIOS‐MS) for drug analysis was investigated. It was observed that only compounds with relative high proton affinity are efficiently ionized under AP‐DIOS conditions. The limits of detection (LODs) achieved in MS mode with midazolam, propranolol, and angiotensin II were 80 fmol, 20 pmol, and 1 pmol, respectively. In MS/MS mode the LODs for midazolam and propranolol were 10 fmol and 5 pmol, respectively. The good linearity (r 2 > 0.991), linear dynamic range of 3 orders of magnitude, and reasonable repeatability showed that the method is suitable for quantitative analysis. Copyright © 2003 John Wiley & Sons, Ltd." @default.
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- W1979730205 date "2003-05-14" @default.
- W1979730205 modified "2023-10-17" @default.
- W1979730205 title "Feasibility of atmospheric pressure desorption/ionization on silicon mass spectrometry in analysis of drugs" @default.
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- W1979730205 doi "https://doi.org/10.1002/rcm.1051" @default.
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