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• W1979736739 endingPage "839" @default.
• W1979736739 startingPage "830" @default.
• W1979736739 abstract "Nod1 is a member of the NLR/Nod/CATERPILLER family. It acts as a sensor for intracellular bacteria by recognizing specific glycopeptides derived from peptidoglycan. Nod1 activation mediates distinct cellular responses including activation of MAP kinases, IL-8 release, apoptosis and suppression of several estrogen-dependent responses in MCF-7 cells. Here we have extended these studies by identifying key regulatory steps in Nod1-dependent signaling pathways. We provide multiple lines of data showing that Nod1-dependent apoptosis is a caspase 8-mediated event and that apoptosis requires RIP2. In contrast, several lines of evidence show that Nod1-dependent JNK activation and IL-8 production did not require the presence of caspase 8 but required activation of TAK1 as well as RIP2. Thus, we have identified several key control points that lie downstream of Nod1. This work provides the basis for further studies of the biological significance and regulation of the Nod1 pathway." @default.
• W1979736739 created "2016-06-24" @default.
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• W1979736739 date "2006-12-22" @default.
• W1979736739 modified "2023-10-10" @default.
• W1979736739 title "Regulation of Nod1-mediated signaling pathways" @default.
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• W1979736739 doi "https://doi.org/10.1038/sj.cdd.4402070" @default.
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