Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979742015> ?p ?o ?g. }
- W1979742015 endingPage "4382" @default.
- W1979742015 startingPage "4367" @default.
- W1979742015 abstract "We report the characterization of a null mutant for zebrafish circadian clock gene period2 (per2) generated by transcription activator-like effector nuclease and a positive role of PER2 in vertebrate circadian regulation. Locomotor experiments showed that per2 mutant zebrafish display reduced activities under light-dark and 2-h phase delay under constant darkness, and quantitative real time PCR analyses showed up-regulation of cry1aa, cry1ba, cry1bb, and aanat2 but down-regulation of per1b, per3, and bmal1b in per2 mutant zebrafish, suggesting that Per2 is essential for the zebrafish circadian clock. Luciferase reporter assays demonstrated that Per2 represses aanat2 expression through E-box and enhances bmal1b expression through the Ror/Rev-erb response element, implicating that Per2 plays dual roles in the zebrafish circadian clock. Cell transfection and co-immunoprecipitation assays revealed that Per2 enhances bmal1b expression through binding to orphan nuclear receptor Rorα. The enhancing effect of mouse PER2 on Bmal1 transcription is also mediated by RORα even though it binds to REV-ERBα. Moreover, zebrafish Per2 also appears to have tissue-specific regulatory roles in numerous peripheral organs. These findings help define the essential functions of Per2 in the zebrafish circadian clock and in particular provide strong evidence for a positive role of PER2 in the vertebrate circadian system." @default.
- W1979742015 created "2016-06-24" @default.
- W1979742015 creator A5003599636 @default.
- W1979742015 creator A5014962417 @default.
- W1979742015 creator A5033022347 @default.
- W1979742015 creator A5065978063 @default.
- W1979742015 creator A5084854649 @default.
- W1979742015 date "2015-02-01" @default.
- W1979742015 modified "2023-10-12" @default.
- W1979742015 title "The Zebrafish Period2 Protein Positively Regulates the Circadian Clock through Mediation of Retinoic Acid Receptor (RAR)-related Orphan Receptor α (Rorα)" @default.
- W1979742015 cites W1629086938 @default.
- W1979742015 cites W1891211155 @default.
- W1979742015 cites W1966006200 @default.
- W1979742015 cites W1966349313 @default.
- W1979742015 cites W1966782228 @default.
- W1979742015 cites W1970570089 @default.
- W1979742015 cites W1975627683 @default.
- W1979742015 cites W1976391205 @default.
- W1979742015 cites W1978780550 @default.
- W1979742015 cites W1979385177 @default.
- W1979742015 cites W1990192893 @default.
- W1979742015 cites W1992365799 @default.
- W1979742015 cites W1995439017 @default.
- W1979742015 cites W2003302378 @default.
- W1979742015 cites W2003643318 @default.
- W1979742015 cites W2005174604 @default.
- W1979742015 cites W2006961929 @default.
- W1979742015 cites W2008789323 @default.
- W1979742015 cites W2014313900 @default.
- W1979742015 cites W2018354024 @default.
- W1979742015 cites W2020972121 @default.
- W1979742015 cites W2021229976 @default.
- W1979742015 cites W2022103697 @default.
- W1979742015 cites W2023831182 @default.
- W1979742015 cites W2025113527 @default.
- W1979742015 cites W2029371145 @default.
- W1979742015 cites W2029808234 @default.
- W1979742015 cites W2035206737 @default.
- W1979742015 cites W2036303851 @default.
- W1979742015 cites W2037750356 @default.
- W1979742015 cites W2039442413 @default.
- W1979742015 cites W2040964766 @default.
- W1979742015 cites W2045955497 @default.
- W1979742015 cites W2046282038 @default.
- W1979742015 cites W2046491820 @default.
- W1979742015 cites W2047799635 @default.
- W1979742015 cites W2052287351 @default.
- W1979742015 cites W2053370182 @default.
- W1979742015 cites W2054513544 @default.
- W1979742015 cites W2060138058 @default.
- W1979742015 cites W2060712753 @default.
- W1979742015 cites W2064693528 @default.
- W1979742015 cites W2064813976 @default.
- W1979742015 cites W2067633308 @default.
- W1979742015 cites W2067885554 @default.
- W1979742015 cites W2077706065 @default.
- W1979742015 cites W2081636325 @default.
- W1979742015 cites W2082351155 @default.
- W1979742015 cites W2084549528 @default.
- W1979742015 cites W2088598710 @default.
- W1979742015 cites W2089749987 @default.
- W1979742015 cites W2091148368 @default.
- W1979742015 cites W2096186352 @default.
- W1979742015 cites W2099472001 @default.
- W1979742015 cites W2101116112 @default.
- W1979742015 cites W2102039847 @default.
- W1979742015 cites W2104290916 @default.
- W1979742015 cites W2104746647 @default.
- W1979742015 cites W2106576941 @default.
- W1979742015 cites W2114838239 @default.
- W1979742015 cites W2122503953 @default.
- W1979742015 cites W2124659072 @default.
- W1979742015 cites W2130069008 @default.
- W1979742015 cites W2137244330 @default.
- W1979742015 cites W2142478420 @default.
- W1979742015 cites W2144479739 @default.
- W1979742015 cites W2150005064 @default.
- W1979742015 cites W2152503338 @default.
- W1979742015 cites W2153581549 @default.
- W1979742015 cites W2153914898 @default.
- W1979742015 cites W2161548459 @default.
- W1979742015 cites W2168271199 @default.
- W1979742015 cites W2169220425 @default.
- W1979742015 cites W2170078281 @default.
- W1979742015 cites W74487872 @default.
- W1979742015 cites W7693602 @default.
- W1979742015 doi "https://doi.org/10.1074/jbc.m114.605022" @default.
- W1979742015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4326843" @default.
- W1979742015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25544291" @default.
- W1979742015 hasPublicationYear "2015" @default.
- W1979742015 type Work @default.
- W1979742015 sameAs 1979742015 @default.
- W1979742015 citedByCount "39" @default.
- W1979742015 countsByYear W19797420152015 @default.
- W1979742015 countsByYear W19797420152016 @default.
- W1979742015 countsByYear W19797420152017 @default.
- W1979742015 countsByYear W19797420152018 @default.
- W1979742015 countsByYear W19797420152019 @default.