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• W1979746578 abstract "The relationship between the concentration of intracellular Ca 2+ ([Ca 2+ ] i ) and recovery from desensitization of nicotinic acetylcholine receptors (nAChRs) in rat medial habenula (MHb) neurons was investigated using the whole cell patch-clamp techniques in combination with microfluoresecent [Ca 2+ ] i measurements. Recovery from desensitization was assessed with a paired-pulse agonist application protocol. Application of 100 μM nicotine (5 s) caused pronounced desensitization of nAChRs, after which recovery proceeded with two components. The relative weight of the two phases of recovery was sensitive to the nature of the intracellular Ca 2+ chelator, with a greater fraction of channels recovering during the fast phase in the presence of BAPTA than EGTA. Recovery was affected by differential Ca 2+ buffering only when Ca 2+ was present in the extracellular solution, implying that Ca 2+ influx through nAChRs was responsible for slowing the recovery. Simultaneous [Ca 2+ ] i measurements showed that recovery from desensitization was inversely correlated with the instantaneous [Ca 2+ ] i , further supporting the suggestion that elevation of [Ca 2+ ] i limits the return of nAChRs to the resting state. In a separate set of experiments, activation of voltage-gated Ca 2+ channels during the recovery phase produced a sufficiently large increase in [Ca 2+ ] i to reduce recovery from desensitization even in the absence of Ca 2+ influx through nAChRs. Overall, it is suggested that Ca 2+ entry through both nAChRs and voltage-gated Ca 2+ channels exerts a negative feedback on nAChR activity through stabilization of desensitized states. The interaction of these two Ca 2+ sources could form the basis of a coincidence detector under specific circumstances." @default.
• W1979746578 created "2016-06-24" @default.
• W1979746578 creator A5060238656 @default.
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• W1979746578 date "2007-01-01" @default.
• W1979746578 modified "2023-09-25" @default.
• W1979746578 title "Regulation of Nicotinic Acetylcholine Receptor Desensitization by Ca²⁺" @default.
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• W1979746578 doi "https://doi.org/10.1152/jn.01047.2005" @default.
• W1979746578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17050825" @default.
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