FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979746613> ?p ?o ?g. }

• W1979746613 endingPage "33" @default.
• W1979746613 startingPage "25" @default.
• W1979746613 abstract "Ataxia-telangiectasia (AT) is a human autosomal recessive disease with a pleiotropic phenotype characterized by cerebellar degeneration, immunodeficiency, premature aging, cancer predisposition, and radiation sensitivity. The gene mutated in AT, ATM (for AT-mutated), had been cloned and found to have ionizing radiation and oxidative stress-inducible kinase activity. No treatment can stop the progression of the disease. In this study, the complete open-reading frame of ATM cDNA was cloned into a Herpes simplex virus type-1 (HSV-1) amplicon vector (pTO-ATM), and the transduction of cultured AT cells was demonstrated by immunohistochemistry and Western blot analysis. Functional gene expression was evaluated by cell colony-forming assays following exposure to oxidative stress. The survival of AT cells with ATM gene transduction was about 100% higher compared to nontransduced cells after t-butyl hydroperoxide treatments. Next, the normal ATM gene expression in different regions of the rat brain was studied. Immunohistochemistry staining demonstrated weak endogenous ATM protein expression in neurons of the caudate-putamen, with significantly higher levels of expression detected in neurons in other brain regions. Exogenous ATM gene expression from pTO-ATM after viral transduction in the caudate-putamen of the adult rat was examined. At 3 days after injection of the pTO-ATM viral vector, abundant positive ATM staining of the neurons was found at the injection sites, in comparison to the controls. These data demonstrate that the relatively large ATM cDNA can be transduced and expressed in vitro and in vivo from an HSV amplicon viral vector. These data provide initial evidence that the replacement of the ATM gene into the cells of AT patients might be possible some day." @default.
• W1979746613 created "2016-06-24" @default.
• W1979746613 creator A5001337409 @default.
• W1979746613 creator A5003312605 @default.
• W1979746613 creator A5005902187 @default.
• W1979746613 creator A5013185342 @default.
• W1979746613 creator A5029500394 @default.
• W1979746613 creator A5051175106 @default.
• W1979746613 creator A5060975265 @default.
• W1979746613 date "2003-12-18" @default.
• W1979746613 modified "2023-10-15" @default.
• W1979746613 title "Functional expression of ATM gene carried by HSV amplicon vector in vitro and in vivo" @default.
• W1979746613 cites W1503107508 @default.
• W1979746613 cites W1566038373 @default.
• W1979746613 cites W1571145613 @default.
• W1979746613 cites W1583466448 @default.
• W1979746613 cites W1670526549 @default.
• W1979746613 cites W1964340993 @default.
• W1979746613 cites W1968788087 @default.
• W1979746613 cites W1970551361 @default.
• W1979746613 cites W1977947450 @default.
• W1979746613 cites W1980737084 @default.
• W1979746613 cites W1983254392 @default.
• W1979746613 cites W1990453326 @default.
• W1979746613 cites W1991037396 @default.
• W1979746613 cites W1991711092 @default.
• W1979746613 cites W1999963842 @default.
• W1979746613 cites W2001931148 @default.
• W1979746613 cites W2002845859 @default.
• W1979746613 cites W2005271958 @default.
• W1979746613 cites W2008393860 @default.
• W1979746613 cites W2008684482 @default.
• W1979746613 cites W2008743975 @default.
• W1979746613 cites W2009660306 @default.
• W1979746613 cites W2013819225 @default.
• W1979746613 cites W2014397152 @default.
• W1979746613 cites W2026406742 @default.
• W1979746613 cites W2030645047 @default.
• W1979746613 cites W2030720512 @default.
• W1979746613 cites W2034629037 @default.
• W1979746613 cites W2036521943 @default.
• W1979746613 cites W2040051736 @default.
• W1979746613 cites W2043546058 @default.
• W1979746613 cites W2048458949 @default.
• W1979746613 cites W2049941746 @default.
• W1979746613 cites W2057382033 @default.
• W1979746613 cites W2062232773 @default.
• W1979746613 cites W2063592469 @default.
• W1979746613 cites W2071431428 @default.
• W1979746613 cites W2073233814 @default.
• W1979746613 cites W2075385153 @default.
• W1979746613 cites W2086005521 @default.
• W1979746613 cites W2087306658 @default.
• W1979746613 cites W2087367816 @default.
• W1979746613 cites W2090399539 @default.
• W1979746613 cites W2092384258 @default.
• W1979746613 cites W2097316296 @default.
• W1979746613 cites W2101719051 @default.
• W1979746613 cites W2116460986 @default.
• W1979746613 cites W2117572685 @default.
• W1979746613 cites W2123073376 @default.
• W1979746613 cites W2125740363 @default.
• W1979746613 cites W2133539385 @default.
• W1979746613 cites W2140386761 @default.
• W1979746613 cites W2159168998 @default.
• W1979746613 cites W2159462562 @default.
• W1979746613 cites W2177597220 @default.
• W1979746613 cites W2327966364 @default.
• W1979746613 cites W2330427748 @default.
• W1979746613 cites W2332552525 @default.
• W1979746613 cites W2887104456 @default.
• W1979746613 cites W4251745863 @default.
• W1979746613 doi "https://doi.org/10.1038/sj.gt.3302140" @default.
• W1979746613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14681694" @default.
• W1979746613 hasPublicationYear "2003" @default.
• W1979746613 type Work @default.
• W1979746613 sameAs 1979746613 @default.
• W1979746613 citedByCount "12" @default.
• W1979746613 countsByYear W19797466132012 @default.
• W1979746613 countsByYear W19797466132014 @default.
• W1979746613 countsByYear W19797466132017 @default.
• W1979746613 countsByYear W19797466132018 @default.
• W1979746613 countsByYear W19797466132019 @default.
• W1979746613 countsByYear W19797466132020 @default.
• W1979746613 crossrefType "journal-article" @default.
• W1979746613 hasAuthorship W1979746613A5001337409 @default.
• W1979746613 hasAuthorship W1979746613A5003312605 @default.
• W1979746613 hasAuthorship W1979746613A5005902187 @default.
• W1979746613 hasAuthorship W1979746613A5013185342 @default.
• W1979746613 hasAuthorship W1979746613A5029500394 @default.
• W1979746613 hasAuthorship W1979746613A5051175106 @default.
• W1979746613 hasAuthorship W1979746613A5060975265 @default.
• W1979746613 hasBestOaLocation W19797466131 @default.
• W1979746613 hasConcept C104317684 @default.
• W1979746613 hasConcept C150194340 @default.
• W1979746613 hasConcept C15152581 @default.
• W1979746613 hasConcept C153911025 @default.
• W1979746613 hasConcept C187882448 @default.

• next