FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979755786> ?p ?o ?g. }

• W1979755786 endingPage "269" @default.
• W1979755786 startingPage "256" @default.
• W1979755786 abstract "Lactoferrin (Lf) is a sialic acid (Sia)-rich, iron-binding milk glycoprotein that has multifunctional health benefits. Its potential role in neurodevelopment and cognition remains unknown. To test the hypothesis that Lf may function to improve neurodevelopment and cognition, the diet of postnatal piglets was supplemented with Lf from days 3 to 38. Expression levels of selected genes and their cognate protein profiles were quantitatively determined. The importance of our new findings is that Lf (1) upregulated several canonical signaling pathways associated with neurodevelopment and cognition; (2) influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway in the hippocampus and upregulated the expression of polysialic acid, a marker of neuroplasticity, cell migration and differentiation of progenitor cells, and the growth and targeting of axons; (3) upregulated transcriptional and translational levels of BDNF and increased phosphorylation of the cyclic adenosine monophosphate (cAMP) response element-binding protein, CREB, a downstream target of the BDNF signaling pathway, and a protein of crucial importance in neurodevelopment and cognition; and (4) enhanced the cognitive function and learning of piglets when tested in an eight-arm radial maze. The finding that Lf can improve neural development and cognition in postnatal piglets has not been previously described." @default.
• W1979755786 created "2016-06-24" @default.
• W1979755786 creator A5002590827 @default.
• W1979755786 creator A5013415958 @default.
• W1979755786 creator A5023531951 @default.
• W1979755786 creator A5044904833 @default.
• W1979755786 creator A5063396957 @default.
• W1979755786 creator A5072855352 @default.
• W1979755786 creator A5076459464 @default.
• W1979755786 creator A5080624375 @default.
• W1979755786 creator A5083119942 @default.
• W1979755786 creator A5083662363 @default.
• W1979755786 date "2014-08-23" @default.
• W1979755786 modified "2023-10-13" @default.
• W1979755786 title "Lactoferrin Promotes Early Neurodevelopment and Cognition in Postnatal Piglets by Upregulating the BDNF Signaling Pathway and Polysialylation" @default.
• W1979755786 cites W115949114 @default.
• W1979755786 cites W1949927726 @default.
• W1979755786 cites W1974723876 @default.
• W1979755786 cites W1979278926 @default.
• W1979755786 cites W1985499970 @default.
• W1979755786 cites W1987910733 @default.
• W1979755786 cites W1990991888 @default.
• W1979755786 cites W2000690906 @default.
• W1979755786 cites W2002172429 @default.
• W1979755786 cites W2003147549 @default.
• W1979755786 cites W2010558905 @default.
• W1979755786 cites W2012423618 @default.
• W1979755786 cites W2019986705 @default.
• W1979755786 cites W2027937844 @default.
• W1979755786 cites W2031790580 @default.
• W1979755786 cites W2033045687 @default.
• W1979755786 cites W2035705986 @default.
• W1979755786 cites W2050610603 @default.
• W1979755786 cites W2052863293 @default.
• W1979755786 cites W2057395623 @default.
• W1979755786 cites W2061733344 @default.
• W1979755786 cites W2065346279 @default.
• W1979755786 cites W2067155791 @default.
• W1979755786 cites W2068412840 @default.
• W1979755786 cites W2075618588 @default.
• W1979755786 cites W2075856578 @default.
• W1979755786 cites W2077581278 @default.
• W1979755786 cites W2078965564 @default.
• W1979755786 cites W2080131125 @default.
• W1979755786 cites W2081920552 @default.
• W1979755786 cites W2082289133 @default.
• W1979755786 cites W2091725248 @default.
• W1979755786 cites W2104583131 @default.
• W1979755786 cites W2105069636 @default.
• W1979755786 cites W2106095767 @default.
• W1979755786 cites W2107495112 @default.
• W1979755786 cites W2109309568 @default.
• W1979755786 cites W2110052715 @default.
• W1979755786 cites W2111978083 @default.
• W1979755786 cites W2113423265 @default.
• W1979755786 cites W2121593446 @default.
• W1979755786 cites W2131545168 @default.
• W1979755786 cites W2132831265 @default.
• W1979755786 cites W2133850147 @default.
• W1979755786 cites W2134709529 @default.
• W1979755786 cites W2140482385 @default.
• W1979755786 cites W2140944550 @default.
• W1979755786 cites W2153753042 @default.
• W1979755786 cites W2155496317 @default.
• W1979755786 cites W2166248226 @default.
• W1979755786 cites W2255943886 @default.
• W1979755786 cites W244713839 @default.
• W1979755786 cites W4230687990 @default.
• W1979755786 doi "https://doi.org/10.1007/s12035-014-8856-9" @default.
• W1979755786 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4510916" @default.
• W1979755786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25146846" @default.
• W1979755786 hasPublicationYear "2014" @default.
• W1979755786 type Work @default.
• W1979755786 sameAs 1979755786 @default.
• W1979755786 citedByCount "75" @default.
• W1979755786 countsByYear W19797557862016 @default.
• W1979755786 countsByYear W19797557862017 @default.
• W1979755786 countsByYear W19797557862018 @default.
• W1979755786 countsByYear W19797557862019 @default.
• W1979755786 countsByYear W19797557862020 @default.
• W1979755786 countsByYear W19797557862021 @default.
• W1979755786 countsByYear W19797557862022 @default.
• W1979755786 countsByYear W19797557862023 @default.
• W1979755786 crossrefType "journal-article" @default.
• W1979755786 hasAuthorship W1979755786A5002590827 @default.
• W1979755786 hasAuthorship W1979755786A5013415958 @default.
• W1979755786 hasAuthorship W1979755786A5023531951 @default.
• W1979755786 hasAuthorship W1979755786A5044904833 @default.
• W1979755786 hasAuthorship W1979755786A5063396957 @default.
• W1979755786 hasAuthorship W1979755786A5072855352 @default.
• W1979755786 hasAuthorship W1979755786A5076459464 @default.
• W1979755786 hasAuthorship W1979755786A5080624375 @default.
• W1979755786 hasAuthorship W1979755786A5083119942 @default.
• W1979755786 hasAuthorship W1979755786A5083662363 @default.
• W1979755786 hasBestOaLocation W19797557861 @default.
• W1979755786 hasConcept C104317684 @default.
• W1979755786 hasConcept C122871604 @default.
• W1979755786 hasConcept C127561419 @default.

• next