FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979757961> ?p ?o ?g. }

• W1979757961 abstract "Chemotherapy is the primary treatment for both resectable and advanced gastric carcinoma, yet multiple drug resistance (MDR) of gastric carcinoma remains a significant therapeutic obstacle. The development of novel strategies to reduce MDR in gastric carcinoma would yield a better outcome following chemotherapy. ING4, a member of the inhibitor of growth (ING) tumor-suppressor family, possesses antitumor and radiosensitization or chemosensitization effects in a variety of human cancers. The present study investigated the effects and possible mechanisms of action of adenovirus-mediated ING4 (AdVING4) on the reversion of human gastric carcinoma cell MDR in vitro and in vivo in nude mouse xenografts. The data showed that the expression of ING4 mRNA and protein was dramatically downregulated (or lost) in gastric carcinoma SGC7901/CDDP cells after CDDP-induced MDR phenotype and in the parental SGC7901 cells. AdVING4‑induced ING4 expression reversed MDR and induced apoptosis of SGC7901/CDDP cells in vitro and in vivo in the SGC7901/CDDP xenograft tumors. Furthermore, AdVING4 substantially downregulated the expression of MDR-related proteins P-gp and MRP1 and apoptosis‑related proteins Bcl-2 and survivin, but upregulated the expression of apoptosis-related protein Bax in the SGC7901/CDDP xenograft tissues. The reversion effects elicited by AdVING4 on gastric cancer cell MDR were closely associated with the downregulation of ATP-binding cassette transporters and activation of apoptotic pathways. Thus, these findings suggest that AdVING4 may be a feasible modulator for the MDR phenotype of gastric carcinoma cells." @default.
• W1979757961 created "2016-06-24" @default.
• W1979757961 creator A5021094234 @default.
• W1979757961 creator A5040840218 @default.
• W1979757961 creator A5071092801 @default.
• W1979757961 creator A5075248303 @default.
• W1979757961 creator A5085025543 @default.
• W1979757961 date "2013-08-20" @default.
• W1979757961 modified "2023-09-29" @default.
• W1979757961 title "Adenovirus-mediated ING4 expression reduces multidrug resistance of human gastric carcinoma cells in vitro and in vivo" @default.
• W1979757961 cites W145339873 @default.
• W1979757961 cites W1482809148 @default.
• W1979757961 cites W1504938069 @default.
• W1979757961 cites W1505376713 @default.
• W1979757961 cites W1508262999 @default.
• W1979757961 cites W1566091992 @default.
• W1979757961 cites W1607777232 @default.
• W1979757961 cites W1893157084 @default.
• W1979757961 cites W1964619238 @default.
• W1979757961 cites W1968108412 @default.
• W1979757961 cites W1969495433 @default.
• W1979757961 cites W1973616414 @default.
• W1979757961 cites W1975308625 @default.
• W1979757961 cites W1975780233 @default.
• W1979757961 cites W1976360640 @default.
• W1979757961 cites W1986138943 @default.
• W1979757961 cites W1997275472 @default.
• W1979757961 cites W2001886938 @default.
• W1979757961 cites W2003605454 @default.
• W1979757961 cites W2004705005 @default.
• W1979757961 cites W2021586632 @default.
• W1979757961 cites W2024374360 @default.
• W1979757961 cites W2032801961 @default.
• W1979757961 cites W2037181582 @default.
• W1979757961 cites W2040613549 @default.
• W1979757961 cites W2057644263 @default.
• W1979757961 cites W2063647772 @default.
• W1979757961 cites W2064269581 @default.
• W1979757961 cites W2066441074 @default.
• W1979757961 cites W2074887253 @default.
• W1979757961 cites W2081363415 @default.
• W1979757961 cites W2082572336 @default.
• W1979757961 cites W2085027690 @default.
• W1979757961 cites W2093105390 @default.
• W1979757961 cites W2105782778 @default.
• W1979757961 cites W2107277218 @default.
• W1979757961 cites W2110504769 @default.
• W1979757961 cites W2115072149 @default.
• W1979757961 cites W2119152345 @default.
• W1979757961 cites W2124149797 @default.
• W1979757961 cites W2133024109 @default.
• W1979757961 cites W2142008486 @default.
• W1979757961 cites W2146609498 @default.
• W1979757961 cites W2147886170 @default.
• W1979757961 cites W2160047329 @default.
• W1979757961 cites W2161370421 @default.
• W1979757961 cites W2170299197 @default.
• W1979757961 cites W336701656 @default.
• W1979757961 doi "https://doi.org/10.3892/or.2013.2671" @default.
• W1979757961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23969950" @default.
• W1979757961 hasPublicationYear "2013" @default.
• W1979757961 type Work @default.
• W1979757961 sameAs 1979757961 @default.
• W1979757961 citedByCount "7" @default.
• W1979757961 countsByYear W19797579612014 @default.
• W1979757961 countsByYear W19797579612015 @default.
• W1979757961 countsByYear W19797579612016 @default.
• W1979757961 countsByYear W19797579612019 @default.
• W1979757961 countsByYear W19797579612020 @default.
• W1979757961 crossrefType "journal-article" @default.
• W1979757961 hasAuthorship W1979757961A5021094234 @default.
• W1979757961 hasAuthorship W1979757961A5040840218 @default.
• W1979757961 hasAuthorship W1979757961A5071092801 @default.
• W1979757961 hasAuthorship W1979757961A5075248303 @default.
• W1979757961 hasAuthorship W1979757961A5085025543 @default.
• W1979757961 hasBestOaLocation W19797579611 @default.
• W1979757961 hasConcept C104317684 @default.
• W1979757961 hasConcept C114851261 @default.
• W1979757961 hasConcept C121608353 @default.
• W1979757961 hasConcept C127561419 @default.
• W1979757961 hasConcept C133936738 @default.
• W1979757961 hasConcept C150903083 @default.
• W1979757961 hasConcept C190283241 @default.
• W1979757961 hasConcept C207001950 @default.
• W1979757961 hasConcept C2775975398 @default.
• W1979757961 hasConcept C2781018059 @default.
• W1979757961 hasConcept C29537977 @default.
• W1979757961 hasConcept C502942594 @default.
• W1979757961 hasConcept C54355233 @default.
• W1979757961 hasConcept C55493867 @default.
• W1979757961 hasConcept C86803240 @default.
• W1979757961 hasConcept C89423630 @default.
• W1979757961 hasConcept C96232424 @default.
• W1979757961 hasConceptScore W1979757961C104317684 @default.
• W1979757961 hasConceptScore W1979757961C114851261 @default.
• W1979757961 hasConceptScore W1979757961C121608353 @default.
• W1979757961 hasConceptScore W1979757961C127561419 @default.
• W1979757961 hasConceptScore W1979757961C133936738 @default.
• W1979757961 hasConceptScore W1979757961C150903083 @default.
• W1979757961 hasConceptScore W1979757961C190283241 @default.

• next