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- W1979758312 endingPage "242" @default.
- W1979758312 startingPage "234" @default.
- W1979758312 abstract "Recent evidence indicates that the lateral parabrachial nucleus (LPBN) in dorsolateral pons is pivotal in mediating the feedback control of inspiratory drive by central chemoreceptor input and feedforward control of body temperature by cutaneous thermoreceptor input. The latter is subject to descending serotonergic inhibition which gates the transmission of ascending thermoafferent information from spinal dorsal horn to the LPBN. Here, a model is proposed which suggests that the LPBN may be important in balancing respiratory and thermal homeostasis, two conflicting goals that are heightened by environmental heat/cold stress or exercise where the effects of respiratory thermolysis become prominent. This optimization model of respiratory–thermoregulatory interaction is supported by a host of recent studies which demonstrate that animals with serotonin (5-HT) dysfunction at the spinal dorsal horn – due to 5-HT antagonism, genetic 5-HT defects or spinal cord injury – all display similar respiratory abnormalities that are consistent with hyperactivity of the spinoparabrachial thermoafferent (and pain) pathway." @default.
- W1979758312 created "2016-06-24" @default.
- W1979758312 creator A5015802672 @default.
- W1979758312 date "2009-12-01" @default.
- W1979758312 modified "2023-10-15" @default.
- W1979758312 title "Optimal interaction of respiratory and thermal regulation at rest and during exercise: Role of a serotonin-gated spinoparabrachial thermoafferent pathway" @default.
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