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• W1979768443 endingPage "57" @default.
• W1979768443 startingPage "21" @default.
• W1979768443 abstract "Abstract The interconversions between right-handed (R) and left-handed (L) helical conformations of DNA have been assessed by spectroscopic, electrophoretic, immunochemical, and enzymatic techniques. We have screened salt and solvent conditions which facilitate these transitions, as well as certain chemical modifications of the bases and backbone of defined synthetic polynucleotides. These include major and minor groove substituents as well as phosphoro- thioate analogues of selected phosphodiester bonds. We have established: • R-L transitions in poly[d(G-C)] with iodo, bromo, methyl, and aza substitutions at the C5 position of cytosine, or phosphorothioate modification of the dGpC linkage. • R-L transitions in the [d(A-C)·d(G-T)]n sequence family using polymers modified as in the case of poly[d(G-C)]. The isomerizations are highly salt and temperature dependent. • a possible L form of poly[d(A-T)] substituted with 2-amino adenine. • the immunogenicities of constitutive and facultative Z-DNAs. • the recognition specificities of different anti-Z-DNA IgGs for the spectrum of available polynucleotide probes. Some IgGs are sequence-specific. • stabilization by IgG of otherwise transient left-handed conformations. • anti-Z-DNA IgG binding to acid-fixed polytene chromosomes from the Diptera Drosophila, Chironomus, and Glyptotendipes. Laser scanning microscopy shows a maximal binding of 1 IgG per 3000–15,000 basepairs in acid fixed preparations. • anti-Z-DNA IgG binding to negatively supercoiled plasmid, viral, phage, and recombinant closed circular DNAs. • transcription from Z and Z* (associated) left-handed templates. From these and other results we propose that Z*-DNA may have important structural- functional roles in the cell." @default.
• W1979768443 created "2016-06-24" @default.
• W1979768443 creator A5005496508 @default.
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• W1979768443 creator A5053884610 @default.
• W1979768443 date "1983-10-01" @default.
• W1979768443 modified "2023-09-27" @default.
• W1979768443 title "Left-handed DNA: from Synthetic Polymers to Chromosomes" @default.
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