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• W1979772308 endingPage "489" @default.
• W1979772308 startingPage "471" @default.
• W1979772308 abstract "Most physiological properties of the lens have been interpreted without explicit reference to the properties of the inner membranes or extracellular space within the tissue. Rather, the lens has been analyzed as if it were a giant spherical cell, ignoring the internal structural complexity known to be present in the tissue. We present measurements which show that the capacitance and conductance of inner membranes and the resistance of the extracellular space are important determinants of the properties of the lens. Measurements were made of the slow response of the lens using either steps of voltage or stochastic currents. The response to stochastic currents was analyzed in bathing solutions of differing potassium concentration to estimate the specific capacitance of the membranes of lens fibers. The specific capacitance varied insignificantly as potassium was varied from 2·5 to 30 mm. This result is expected if the slow response of the lens arises from the dielectric properties of the membranes of the lens fibers; it is not expected if the slow response is produced by changes in potassium concentration in the extracellular space. The response to stochastic currents in bathing solutions of varying conductivity was also measured and analyzed to estimate the distributed resistance in series with the membranes of the lens fibers. The distributed series resistance was found to double when the extracellular conductivity was decreased by a factor of 1·9, suggesting that the distributed series resistance is in fact produced by the resistance of the solution in the extracellular space within the lens. The transient current flowing in response to a step voltage was measured in two solutions of different conductivity. The time course of the current was substantially different in the two solutions, showing that the conductivity of the extracellular solution between lens fibers has a dramatic effect on the electrical properties of the lens. These results support the previous conclusions that inner membranes and extracellular space between lens fibers are both important determinants of the overall properties of the lens. We suggest that physiological measurements of the overall properties of a lens — whether of isotopic flux, ionic current, or voltage — cannot be interpreted as the properties of a single membrane. Rather, they must be interpreted as the response of a syncytial tissue, with important contributions from inner and outer membranes and extracellular space." @default.
• W1979772308 created "2016-06-24" @default.
• W1979772308 creator A5031408337 @default.
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• W1979772308 date "1982-11-01" @default.
• W1979772308 modified "2023-09-23" @default.
• W1979772308 title "Physiological role of the membranes and extracellular space within the ocular lens" @default.
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• W1979772308 doi "https://doi.org/10.1016/0014-4835(82)90044-6" @default.
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• W1979772308 hasPublicationYear "1982" @default.
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