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- W1979777680 abstract "The effects of congenital monocular microphthalmia on the development of the lateral geniculate nucleus were examined in a 10-week-old cat. The left eye and optic nerve in this animal appear normal. The right eye is about 30% smaller in volume than the left and the optic nerve from this eye has a cross-sectional area that is only 15% that of the left. In addition, this nerve contains few, if any, large myelinated axons. Both lateral geniculate nuclei are abnormal and the abnormality differs rostrally and caudally. The caudal portion most closely resembles the normal nucleus. Retinal input from both eyes is segregated into cellular laminae that are separated from each other by cell sparse interlaminar zones. However, the input from the microphthalmic eye seems to be sparse and patchy and it does not support normal cell growth. All neurons, including glutamic acid decarboxylase-positive (GAD+) neurons, in laminae innervated by the small eye are reduced in size in a pattern similar to that seen following the removal of retinal input. In comparison, the rostral portion of the nucleus receives very little input from the microphthalmic eye. Instead the normal eye densely innervates nearly the entire nucleus. In this region, interlaminar zones fail to form but the input from the normal eye is able to support cell growth including the growth of GAD+ neurons." @default.
- W1979777680 created "2016-06-24" @default.
- W1979777680 creator A5023215460 @default.
- W1979777680 date "1987-05-01" @default.
- W1979777680 modified "2023-09-26" @default.
- W1979777680 title "Organization of the dorsal lateral geniculate nucleus in a cat with congenital microphthalmia" @default.
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- W1979777680 doi "https://doi.org/10.1016/0165-3806(87)90178-7" @default.
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