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- W1979780089 abstract "To obtain the initial crystallization hit and the subsequent optimization remain the major bottlenecks in membrane protein structure determination. Here we describe an approach to achieve diffraction quality membrane protein crystals in high concentrations of lipid and detergent (HILIDE). Initial hits are achieved through a controlled variation of the membrane protein/lipid/detergent ratios, and optimized crystals are established by systematic screening with secondary detergents at concentrations that are adapted for the method. The approach is generally applicable for native and heterologously expressed membrane proteins, and it is compatible with any crystallization method, such as vapor diffusion and batch crystallization under oil. The method provides a user defined lipidic environment and is in itself not limited to lipids with particular properties, such as the lipid-phase crystallization methods." @default.
- W1979780089 created "2016-06-24" @default.
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- W1979780089 date "2011-05-13" @default.
- W1979780089 modified "2023-10-03" @default.
- W1979780089 title "HiLiDe—Systematic Approach to Membrane Protein Crystallization in Lipid and Detergent" @default.
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- W1979780089 doi "https://doi.org/10.1021/cg101360d" @default.
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