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- W1979803203 abstract "The action of parasympathico-mimetic drugs (acetylcholine, physostigmine, pilocarpine) and of GABA on the spontaneous or evoked electrical brain activities has been analyzed with the technique of Monnier and Gangloff (1961). These drugs, injected in the common carotid artery, produce the following electrophysiological alterations: (a) arousal syndrome characterized by desynchronized electrical activities in the neocortex with synchronization in the hippocampus, caudate nucleus, thalamus and midbrain reticular system; (b) increased arousal reaction to sensory and reticular stimuli; (c) slightly increased cortical potentials evoked by stimulation of the reticular system; (d) markedly increased cortical potentials evoked by stimulation of the hippocampus and caudate nucleus; (e) decreased recruiting potentials evoked by stimulation of the medial thalamus; (f) unaltered or slightly decreased cortical potentials evoked by stimulation of the ventrolateral thalamus. Most of these effects were suppressed by atropine. These facts prove the existence of cholinoceptive substrates inhibiting synchronization in the neocortex and of other cholinoceptive substrates facilitating synchronization in the archicortex (hippocampus) and caudate nucleus. The action of GABA is very often similar to that of acetylcholine and other parasympathico-mimetic drugs." @default.
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- W1979803203 date "1962-08-01" @default.
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- W1979803203 title "Les systèmes cholinoceptifs cérébraux — actions de l'acétylcholine, de la physostigmine, pilocarpine et de gaba" @default.
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- W1979803203 doi "https://doi.org/10.1016/0013-4694(62)90054-8" @default.
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