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- W1979828619 abstract "A case of Evans' syndrome with IgM deficiency and lymphopenia was studied before and after splenectomy. The lymphopenia was as a result of profound reduction of CD4 and CD8 cells. Study of cytokine secretion before splenectomy revealed a spontaneous Th1- and Th2-type cytokine production, and complete suppression of transforming growth factor (TGF)-beta. After splenectomy, the patient achieved clinical remission, the natural killer (NK) cell number increased and the pattern of cytokine production showed normalization of interleukin (IL)-2, IL-4, IL-10, TGF-beta and abolition of interferon (IFN)-gamma production. We conclude that splenectomy had a beneficial effect owing to an increase in NK cells and an associated increase in TGF-beta production." @default.
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- W1979828619 date "2000-09-01" @default.
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- W1979828619 title "Th1 and Th2 cytokines in a patient with Evans' syndrome and profound lymphopenia" @default.
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- W1979828619 doi "https://doi.org/10.1046/j.1365-2141.2000.02296.x" @default.
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