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• W1979842661 startingPage "e62414" @default.
• W1979842661 abstract "Autapses are connections between a neuron and itself. These connections are morphologically similar to “normal” synapses between two different neurons, and thus were long thought to have similar properties of synaptic transmission. However, this has not been directly tested. Here, using a micro-island culture assay in which we can define the number of interconnected cells, we directly compared synaptic transmission in excitatory autapses and in two-neuron micronetworks consisting of two excitatory neurons, in which a neuron is connected to one other neuron and to itself. We discovered that autaptic synapses are optimized for maximal transmission, and exhibited enhanced EPSC amplitude, charge, and RRP size compared to interneuronal synapses. However, autapses are deficient in several aspects of synaptic plasticity. Short-term potentiation only became apparent when a neuron was connected to another neuron. This acquisition of plasticity only required reciprocal innervation with one other neuron; micronetworks consisting of just two interconnected neurons exhibited enhanced short-term plasticity in terms of paired pulse ratio (PPR) and release probability (Pr), compared to autapses. Interestingly, when a neuron was connected to another neuron, not only interneuronal synapses, but also the autaptic synapses on itself exhibited a trend toward enhanced short-term plasticity in terms of PPR and Pr. Thus neurons can distinguish whether they are connected via “self” or “non-self” synapses and have the ability to adjust their plasticity parameters when connected to other neurons." @default.
• W1979842661 created "2016-06-24" @default.
• W1979842661 creator A5010308883 @default.
• W1979842661 creator A5021867494 @default.
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• W1979842661 date "2013-04-29" @default.
• W1979842661 modified "2023-09-24" @default.
• W1979842661 title "“Self” versus “Non-Self” Connectivity Dictates Properties of Synaptic Transmission and Plasticity" @default.
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• W1979842661 doi "https://doi.org/10.1371/journal.pone.0062414" @default.
• W1979842661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3639172" @default.
• W1979842661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23658626" @default.
• W1979842661 hasPublicationYear "2013" @default.
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