Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979844379> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1979844379 endingPage "43" @default.
- W1979844379 startingPage "37" @default.
- W1979844379 abstract "Ras-oncogene activation was investigated in the bladder tumors of F344 male rats given N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in drinking water. DNA from one of the nine transitional cell carcinomas contained an H-ras oncogene detectable by the NIH/3T3 transfection assay. Analysis of p21 ras proteins suggested that the activating mutation resided within codon 61 of the H-ras gene and that such activating mutations were not present in other tumors. In contrast to mutational activation of ras genes, enhanced expression of p21 was observed in all tumors examined by immunohistochemical techniques with the use of Formalin-fixed paraffin-embedded tissue sections and an anti-ras p21 antibody, RAP-5. Further histochemical analysis of bladder tissues at various stages of the BBN-induced carcinogenic process indicated that the enhanced expression of p21 appeared early; the reactivity with RAP-5 was observed in diffuse hyperplastic epithelia after 5 weeks of exposure to BBN. The frequency of ras oncogenes, activated either by point mutations or overexpression of p21, in BBN-induced rat bladder carcinomas has thus been shown to be similar to that observed in human bladder carcinomas." @default.
- W1979844379 created "2016-06-24" @default.
- W1979844379 creator A5015969598 @default.
- W1979844379 creator A5016679916 @default.
- W1979844379 creator A5029697081 @default.
- W1979844379 creator A5031359076 @default.
- W1979844379 creator A5047497347 @default.
- W1979844379 creator A5072547827 @default.
- W1979844379 creator A5079458533 @default.
- W1979844379 date "1988-03-02" @default.
- W1979844379 modified "2023-10-16" @default.
- W1979844379 title "Activation of H-ras Oncogene in Rat Bladder Tumors Induced by N-Butyl-N-(4-hydroxybutyl)nitrosamine1" @default.
- W1979844379 doi "https://doi.org/10.1093/jnci/80.1.37" @default.
- W1979844379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3276902" @default.
- W1979844379 hasPublicationYear "1988" @default.
- W1979844379 type Work @default.
- W1979844379 sameAs 1979844379 @default.
- W1979844379 citedByCount "23" @default.
- W1979844379 countsByYear W19798443792016 @default.
- W1979844379 countsByYear W19798443792021 @default.
- W1979844379 crossrefType "journal-article" @default.
- W1979844379 hasAuthorship W1979844379A5015969598 @default.
- W1979844379 hasAuthorship W1979844379A5016679916 @default.
- W1979844379 hasAuthorship W1979844379A5029697081 @default.
- W1979844379 hasAuthorship W1979844379A5031359076 @default.
- W1979844379 hasAuthorship W1979844379A5047497347 @default.
- W1979844379 hasAuthorship W1979844379A5072547827 @default.
- W1979844379 hasAuthorship W1979844379A5079458533 @default.
- W1979844379 hasConcept C104317684 @default.
- W1979844379 hasConcept C114246631 @default.
- W1979844379 hasConcept C121608353 @default.
- W1979844379 hasConcept C126322002 @default.
- W1979844379 hasConcept C142724271 @default.
- W1979844379 hasConcept C153911025 @default.
- W1979844379 hasConcept C176944494 @default.
- W1979844379 hasConcept C185592680 @default.
- W1979844379 hasConcept C204232928 @default.
- W1979844379 hasConcept C2777395278 @default.
- W1979844379 hasConcept C2779762690 @default.
- W1979844379 hasConcept C2780352672 @default.
- W1979844379 hasConcept C2781018059 @default.
- W1979844379 hasConcept C29537977 @default.
- W1979844379 hasConcept C501734568 @default.
- W1979844379 hasConcept C502942594 @default.
- W1979844379 hasConcept C54009773 @default.
- W1979844379 hasConcept C54355233 @default.
- W1979844379 hasConcept C555283112 @default.
- W1979844379 hasConcept C71924100 @default.
- W1979844379 hasConcept C86803240 @default.
- W1979844379 hasConceptScore W1979844379C104317684 @default.
- W1979844379 hasConceptScore W1979844379C114246631 @default.
- W1979844379 hasConceptScore W1979844379C121608353 @default.
- W1979844379 hasConceptScore W1979844379C126322002 @default.
- W1979844379 hasConceptScore W1979844379C142724271 @default.
- W1979844379 hasConceptScore W1979844379C153911025 @default.
- W1979844379 hasConceptScore W1979844379C176944494 @default.
- W1979844379 hasConceptScore W1979844379C185592680 @default.
- W1979844379 hasConceptScore W1979844379C204232928 @default.
- W1979844379 hasConceptScore W1979844379C2777395278 @default.
- W1979844379 hasConceptScore W1979844379C2779762690 @default.
- W1979844379 hasConceptScore W1979844379C2780352672 @default.
- W1979844379 hasConceptScore W1979844379C2781018059 @default.
- W1979844379 hasConceptScore W1979844379C29537977 @default.
- W1979844379 hasConceptScore W1979844379C501734568 @default.
- W1979844379 hasConceptScore W1979844379C502942594 @default.
- W1979844379 hasConceptScore W1979844379C54009773 @default.
- W1979844379 hasConceptScore W1979844379C54355233 @default.
- W1979844379 hasConceptScore W1979844379C555283112 @default.
- W1979844379 hasConceptScore W1979844379C71924100 @default.
- W1979844379 hasConceptScore W1979844379C86803240 @default.
- W1979844379 hasIssue "1" @default.
- W1979844379 hasLocation W19798443791 @default.
- W1979844379 hasLocation W19798443792 @default.
- W1979844379 hasOpenAccess W1979844379 @default.
- W1979844379 hasPrimaryLocation W19798443791 @default.
- W1979844379 hasRelatedWork W1874556631 @default.
- W1979844379 hasRelatedWork W201987165 @default.
- W1979844379 hasRelatedWork W2083531614 @default.
- W1979844379 hasRelatedWork W2133654558 @default.
- W1979844379 hasRelatedWork W2141872609 @default.
- W1979844379 hasRelatedWork W2516335369 @default.
- W1979844379 hasRelatedWork W2585735115 @default.
- W1979844379 hasRelatedWork W2763993767 @default.
- W1979844379 hasRelatedWork W2801335122 @default.
- W1979844379 hasRelatedWork W3142054626 @default.
- W1979844379 hasVolume "80" @default.
- W1979844379 isParatext "false" @default.
- W1979844379 isRetracted "false" @default.
- W1979844379 magId "1979844379" @default.
- W1979844379 workType "article" @default.