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• W1979852029 abstract "Atomoxetine affects transcription/translation of the NMDA receptor and the norepinephrine transporter in the rat brain – an in vivo study Patrick T Udvardi,1,2 Karl J Föhr,3 Carolin Henes,1,2 Stefan Liebau,2 Jens Dreyhaupt,4 Tobias M Boeckers,2 Andrea G Ludolph11Department of Child and Adolescent Psychiatry and Psychotherapy, 2Institute of Anatomy and Cell Biology, 3Department of Anaesthesiology, 4Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, GermanyAbstract: Attention-deficit/hyperactivity disorder (ADHD) is the most frequently diagnosed neurodevelopmental disorder. The norepinephrine transporter (NET) inhibitor atomoxetine, the first nonstimulant drug licensed for ADHD treatment, also acts as an N-methyl-D-aspartate receptor (NMDAR) antagonist. The compound&#39;s effects on gene expression and protein levels of NET and NMDAR subunits (1, 2A, and 2B) are unknown. Therefore, adolescent Sprague Dawley rats were treated with atomoxetine (3 mg/kg, intraperitoneal injection [ip]) or saline (0.9%, ip) for 21 consecutive days on postnatal days (PND) 21–41. In humans, atomoxetine&#39;s earliest clinical therapeutic effects emerge after 2–3 weeks. Material from prefrontal cortex, striatum (STR), mesencephalon (MES), and hippocampus (HC) was analyzed either directly after treatment (PND 42) or 2 months after termination of treatment (PND 101) to assess the compound&#39;s long-term effects. In rat brains analyzed immediately after treatment, protein analysis exhibited decreased levels of the NET in HC, and NMDAR subunit 2B in both STR and HC; the transcript levels were unaltered. In rat brains probed 2 months after final atomoxetine exposure, messenger RNA analysis also revealed significantly reduced levels of genes coding for NMDAR subunits in MES and STR. NMDAR protein levels were reduced in STR and HC. Furthermore, the levels of two SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins, synaptophysin and synaptosomal-associated protein 25, were also significantly altered in both treatment groups. This in vivo study detected atomoxetine&#39;s effects beyond NET inhibition. Taken together, these data reveal that atomoxetine seems to decrease glutamatergic transmission in a brain region-specific manner. Long-term data show that the compound&#39;s impact is not due to an acute pharmacological effect but lasts or even amplifies after a drug-free period of 2 months, leading to altered development of synaptic composition. These alterations might contribute to atomoxetine&#39;s clinical effects in the treatment of ADHD, a neurodevelopmental disorder in which synaptic processes and especially a dysregulated glutamatergic metabolism seem to be involved.Keywords: attention-deficit hyperactivity disorder (ADHD), neurodevelopment, atomoxetine, in vivo study, altered gene expression, N-methyl-D-aspartate receptor" @default.
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• W1979852029 date "2013-12-01" @default.
• W1979852029 modified "2023-10-03" @default.
• W1979852029 title "Atomoxetine affects transcription/translation of the NMDA receptor and the norepinephrine transporter in the rat brain &ndash; an in vivo study" @default.
• W1979852029 cites W1524110814 @default.
• W1979852029 cites W1530918435 @default.
• W1979852029 cites W1577577364 @default.
• W1979852029 cites W1908021040 @default.
• W1979852029 cites W1928314647 @default.
• W1979852029 cites W1970064208 @default.
• W1979852029 cites W1977761077 @default.
• W1979852029 cites W1978427046 @default.
• W1979852029 cites W1980032779 @default.
• W1979852029 cites W1982047175 @default.
• W1979852029 cites W1982266128 @default.
• W1979852029 cites W1984858305 @default.
• W1979852029 cites W1987164572 @default.
• W1979852029 cites W1995680954 @default.
• W1979852029 cites W2003179182 @default.
• W1979852029 cites W2005800358 @default.
• W1979852029 cites W2011830495 @default.
• W1979852029 cites W2012641732 @default.
• W1979852029 cites W2024847016 @default.
• W1979852029 cites W2027792516 @default.
• W1979852029 cites W2034040733 @default.
• W1979852029 cites W2036650593 @default.
• W1979852029 cites W2040970438 @default.
• W1979852029 cites W2041024256 @default.
• W1979852029 cites W2041404902 @default.
• W1979852029 cites W2044795903 @default.
• W1979852029 cites W2045089703 @default.
• W1979852029 cites W2045118876 @default.
• W1979852029 cites W2047534841 @default.
• W1979852029 cites W2055102381 @default.
• W1979852029 cites W2055324794 @default.
• W1979852029 cites W2057760214 @default.
• W1979852029 cites W2061413929 @default.
• W1979852029 cites W2065169750 @default.
• W1979852029 cites W2065848862 @default.
• W1979852029 cites W2066179547 @default.
• W1979852029 cites W2067261800 @default.
• W1979852029 cites W2067580023 @default.
• W1979852029 cites W2069069376 @default.
• W1979852029 cites W2069777578 @default.
• W1979852029 cites W2079516818 @default.
• W1979852029 cites W2079788920 @default.
• W1979852029 cites W2081070804 @default.
• W1979852029 cites W2082497364 @default.
• W1979852029 cites W2082791664 @default.
• W1979852029 cites W2085046856 @default.
• W1979852029 cites W2094698442 @default.
• W1979852029 cites W2097155839 @default.
• W1979852029 cites W2097323670 @default.
• W1979852029 cites W2104956231 @default.
• W1979852029 cites W2113747602 @default.
• W1979852029 cites W2116098051 @default.
• W1979852029 cites W2116635659 @default.
• W1979852029 cites W2117949808 @default.
• W1979852029 cites W2121239869 @default.
• W1979852029 cites W2121435418 @default.
• W1979852029 cites W2122518346 @default.
• W1979852029 cites W2125138227 @default.
• W1979852029 cites W2126551185 @default.
• W1979852029 cites W2127692959 @default.
• W1979852029 cites W2128574573 @default.
• W1979852029 cites W2138650756 @default.
• W1979852029 cites W2139951657 @default.
• W1979852029 cites W2140774080 @default.
• W1979852029 cites W2141984765 @default.
• W1979852029 cites W2144385879 @default.
• W1979852029 cites W2144633011 @default.
• W1979852029 cites W2145440976 @default.
• W1979852029 cites W2146521940 @default.
• W1979852029 cites W2153203146 @default.
• W1979852029 cites W2154100802 @default.
• W1979852029 cites W2159881136 @default.
• W1979852029 cites W2163815564 @default.
• W1979852029 cites W2171074660 @default.
• W1979852029 cites W2408392528 @default.
• W1979852029 cites W2066201328 @default.
• W1979852029 cites W2255177070 @default.
• W1979852029 doi "https://doi.org/10.2147/dddt.s50448" @default.
• W1979852029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3857115" @default.
• W1979852029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24348020" @default.
• W1979852029 hasPublicationYear "2013" @default.
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