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• W1979855036 abstract "Exercise capacity is reduced in patients with end-stage renal disease on maintenance home peritoneal dialysis therapy, although the potential mechanisms and clinical implications remain unclear.Cross-sectional study.95 ambulatory prevalent and incident peritoneal dialysis patients in a well-established renal dialysis center (mean age, 58.26 ± 12.6 [SD] years; 63% men; mean duration of peritoneal dialysis therapy, 3.2 ± 4.1 years).Estimated volume status using spectral bioelectrical impedance, echocardiography-derived hemodynamic parameters.Exercise capacity measured as peak oxygen consumption using symptom-limiting treadmill exercise testing.Exercise capacity was reduced in 96% of patients and severely reduced in 65%. Extracellular to intracellular fluid volume ratio showed the strongest correlation with reduced exercise capacity (R = -0.63; P < 0.001) and was superior to age, pulmonary capillary wedge pressure (E:E' ratio), lean tissue mass index, and hemoglobin and albumin levels in predicting exercise intolerance.Relatively small sample size and echocardiogram that was performed only at rest.There was a strong relationship between body extracellular to intracellular fluid volume ratio and exercise capacity in peritoneal dialysis patients. These findings provide new evidence for a connection between fluid distribution, muscle mass, and exercise capacity. Therapeutic strategies targeting fluid status and muscle mass may improve the exercise capacity of patients on peritoneal dialysis therapy." @default.
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• W1979855036 date "2013-11-01" @default.
• W1979855036 modified "2023-10-01" @default.
• W1979855036 title "Prevalence of and Associations With Reduced Exercise Capacity in Peritoneal Dialysis Patients" @default.
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• W1979855036 doi "https://doi.org/10.1053/j.ajkd.2013.05.016" @default.
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