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- W1979857372 abstract "Abstract The tissue distribution and morphology of various subsets reacting with Orthoclone monoclonal antibodies (OKT series) have been analysed in the human thymus, bone marrow, peripheral lymphoid organs and the gut. In the thymus four major types of lymphoid cells can be distinguished: large thymic blasts (0.5–5%; putative thymic precursors, which show some similarities to terminal deoxynucleotidyl transferase positive bone marrow cells), typical cortical thymocytes (70–75%), intermediate forms (10–15%) and typical medullary thymocytes (10–15%) with peripheral T cell characteristics. T cells of “inducer” and “suppressor-cytotoxic” phenotypes seem to be generated within the thymus. OKT4+, OKT5−, 8− cells of the inducer type predominate in the thymic medulla, blood and T cell traffic areas, such as tonsillar paracortex and intestinal lamina propria. OKT4−4, OKT5+, 8− cells of the suppressor-cytotoxic type, on the other hand, constitute the larger part of the T cell population in normal human bone marrow and gut epithelium. A close microanatomical relationship exist between the OKT4+, OKT5−, 8− cells and non-lymphoid cells expressing large amounts of la-like (p28, 33) antigens. These Ia+ interdigitating (ID) cells in tonsil and lymph nodes and Ia+ macrophages in the gut may play a part in the local regulation of inducer T cell activity. Thus the T cell subsets which have been shown to have different functions in previous studies in vitro seem to have different tissue distribution. This implies that T cell subsets have different immunological roles in vivo." @default.
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- W1979857372 date "1981-01-01" @default.
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- W1979857372 title "Subpopulations of human T lymphocytes occupy different microenvironments" @default.
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- W1979857372 doi "https://doi.org/10.1016/0192-0561(81)90015-1" @default.
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