FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979857580> ?p ?o ?g. }

• W1979857580 endingPage "517" @default.
• W1979857580 startingPage "509" @default.
• W1979857580 abstract "Replication of prions is dependent on the presence of the host protein PrPc. During the course of disease, PrPc is converted into an abnormal isoform, PrPSc, which accumulates in the brain. Attempts to identify the cell type(s) in which prion replication and PrP conversion occur have reached conflicting results. Although PrP mRNA is present in high amounts in neurons throughout the life of the animal, PrPSc initially accumulates in astrocytes and possibly other glial cells and, later in the course of the disease, spreads diffusely in the tissue, often in white matter. We report here that PrP mRNA is expressed not only in neurons but also in astrocytes and oligodendrocytes throughout the brain of postnatal hamsters and rats. The level of glial Prp mRNA expression in neonatal animals was comparable to that of neurons and increased two-fold during postnatal development. A substantial portion of brain PrP mRNA is therefore contributed by glial cells. Our results provide an explanation for the accumulation of PrPSc in white matter tissue and in the cytoplasm of glial cells and argue for a direct involvement of glia in prion propagation." @default.
• W1979857580 created "2016-06-24" @default.
• W1979857580 creator A5025939467 @default.
• W1979857580 creator A5049650220 @default.
• W1979857580 creator A5060011272 @default.
• W1979857580 creator A5060535412 @default.
• W1979857580 date "1995-03-01" @default.
• W1979857580 modified "2023-10-12" @default.
• W1979857580 title "Developmental expression of the prion protein gene in glial cells" @default.
• W1979857580 cites W1533604120 @default.
• W1979857580 cites W1785632316 @default.
• W1979857580 cites W1819988191 @default.
• W1979857580 cites W1972409470 @default.
• W1979857580 cites W1975723177 @default.
• W1979857580 cites W1980099107 @default.
• W1979857580 cites W1983750916 @default.
• W1979857580 cites W1983998410 @default.
• W1979857580 cites W1986363632 @default.
• W1979857580 cites W1988467528 @default.
• W1979857580 cites W1990497827 @default.
• W1979857580 cites W1991953925 @default.
• W1979857580 cites W1993681905 @default.
• W1979857580 cites W1995292786 @default.
• W1979857580 cites W2009379306 @default.
• W1979857580 cites W2014742609 @default.
• W1979857580 cites W2021834993 @default.
• W1979857580 cites W2022442770 @default.
• W1979857580 cites W2023773575 @default.
• W1979857580 cites W2027122625 @default.
• W1979857580 cites W2029428782 @default.
• W1979857580 cites W2030353557 @default.
• W1979857580 cites W2032379145 @default.
• W1979857580 cites W2033699178 @default.
• W1979857580 cites W2034754449 @default.
• W1979857580 cites W2036323288 @default.
• W1979857580 cites W2036645353 @default.
• W1979857580 cites W2037281517 @default.
• W1979857580 cites W2042978244 @default.
• W1979857580 cites W2051968416 @default.
• W1979857580 cites W2060295481 @default.
• W1979857580 cites W2064456465 @default.
• W1979857580 cites W2065193233 @default.
• W1979857580 cites W2067437467 @default.
• W1979857580 cites W2068467995 @default.
• W1979857580 cites W2072244190 @default.
• W1979857580 cites W2076453977 @default.
• W1979857580 cites W2082766785 @default.
• W1979857580 cites W2083045022 @default.
• W1979857580 cites W2083092470 @default.
• W1979857580 cites W2087826502 @default.
• W1979857580 cites W2090363643 @default.
• W1979857580 cites W2103129775 @default.
• W1979857580 cites W2110420813 @default.
• W1979857580 cites W2115280754 @default.
• W1979857580 cites W2133392411 @default.
• W1979857580 cites W2137548599 @default.
• W1979857580 cites W2147966233 @default.
• W1979857580 cites W2168541092 @default.
• W1979857580 cites W2314269495 @default.
• W1979857580 cites W4294216491 @default.
• W1979857580 cites W4298258225 @default.
• W1979857580 doi "https://doi.org/10.1016/0896-6273(95)90307-0" @default.
• W1979857580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7695897" @default.
• W1979857580 hasPublicationYear "1995" @default.
• W1979857580 type Work @default.
• W1979857580 sameAs 1979857580 @default.
• W1979857580 citedByCount "299" @default.
• W1979857580 countsByYear W19798575802012 @default.
• W1979857580 countsByYear W19798575802013 @default.
• W1979857580 countsByYear W19798575802014 @default.
• W1979857580 countsByYear W19798575802015 @default.
• W1979857580 countsByYear W19798575802016 @default.
• W1979857580 countsByYear W19798575802017 @default.
• W1979857580 countsByYear W19798575802018 @default.
• W1979857580 countsByYear W19798575802019 @default.
• W1979857580 countsByYear W19798575802020 @default.
• W1979857580 countsByYear W19798575802021 @default.
• W1979857580 countsByYear W19798575802022 @default.
• W1979857580 countsByYear W19798575802023 @default.
• W1979857580 crossrefType "journal-article" @default.
• W1979857580 hasAuthorship W1979857580A5025939467 @default.
• W1979857580 hasAuthorship W1979857580A5049650220 @default.
• W1979857580 hasAuthorship W1979857580A5060011272 @default.
• W1979857580 hasAuthorship W1979857580A5060535412 @default.
• W1979857580 hasBestOaLocation W19798575801 @default.
• W1979857580 hasConcept C104317684 @default.
• W1979857580 hasConcept C105580179 @default.
• W1979857580 hasConcept C126838900 @default.
• W1979857580 hasConcept C143409427 @default.
• W1979857580 hasConcept C1491633281 @default.
• W1979857580 hasConcept C150194340 @default.
• W1979857580 hasConcept C169760540 @default.
• W1979857580 hasConcept C189014844 @default.
• W1979857580 hasConcept C190062978 @default.
• W1979857580 hasConcept C203014093 @default.
• W1979857580 hasConcept C2776914184 @default.
• W1979857580 hasConcept C2776985911 @default.
• W1979857580 hasConcept C2777542381 @default.

• next