Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979858170> ?p ?o ?g. }
- W1979858170 endingPage "3451" @default.
- W1979858170 startingPage "3447" @default.
- W1979858170 abstract "It has long been known that excesses of glucose and branched chain amino acids, such as leucine, lead to insulin resistance in skeletal muscle. A recent study in incubated rat muscle suggests that both molecules may do so by virtue of their ability to downregulate the fuel sensing and signaling enzyme AMP-activated protein kinase (AMPK) and activate mTOR/p70S6 kinase (p70S6K) signaling. The results also demonstrated that inhibition of mTOR/p70S6K with rapamycin prevented the development of insulin resistance but had no effect on AMPK activity (Thr172 phosphorylation of its catalytic subunit). In contrast, activation of AMPK by both AICAR and α-lipoic acid led to the phosphorylation of specific molecules that diminished both mTOR/p70S6K signaling and insulin resistance. These findings suggest that downregulation of AMPK precedes mTOR/p70S6K activation in mediating glucose and leucine-induced insulin resistance, although the mechanism by which it does so remains to be determined. Also requiring study is how an excess of the two nutrients leads to AMPK downregulation." @default.
- W1979858170 created "2016-06-24" @default.
- W1979858170 creator A5017460289 @default.
- W1979858170 creator A5033235128 @default.
- W1979858170 creator A5055882378 @default.
- W1979858170 creator A5068371835 @default.
- W1979858170 creator A5074667950 @default.
- W1979858170 creator A5084058345 @default.
- W1979858170 date "2011-10-15" @default.
- W1979858170 modified "2023-10-16" @default.
- W1979858170 title "Insulin resistance due to nutrient excess" @default.
- W1979858170 cites W177963654 @default.
- W1979858170 cites W1784343836 @default.
- W1979858170 cites W1973163466 @default.
- W1979858170 cites W1983336199 @default.
- W1979858170 cites W2008626933 @default.
- W1979858170 cites W2011001343 @default.
- W1979858170 cites W2015022497 @default.
- W1979858170 cites W2015173256 @default.
- W1979858170 cites W2017771330 @default.
- W1979858170 cites W2030455994 @default.
- W1979858170 cites W2031372661 @default.
- W1979858170 cites W2032983681 @default.
- W1979858170 cites W2033004791 @default.
- W1979858170 cites W2034110828 @default.
- W1979858170 cites W2055579594 @default.
- W1979858170 cites W2062801148 @default.
- W1979858170 cites W2067152194 @default.
- W1979858170 cites W2074303577 @default.
- W1979858170 cites W2076002276 @default.
- W1979858170 cites W2076692736 @default.
- W1979858170 cites W2080192652 @default.
- W1979858170 cites W2081993609 @default.
- W1979858170 cites W2083393831 @default.
- W1979858170 cites W2088184211 @default.
- W1979858170 cites W2090744673 @default.
- W1979858170 cites W2094355037 @default.
- W1979858170 cites W2094632969 @default.
- W1979858170 cites W2096979086 @default.
- W1979858170 cites W2101885674 @default.
- W1979858170 cites W2117026649 @default.
- W1979858170 cites W2122338853 @default.
- W1979858170 cites W2122367003 @default.
- W1979858170 cites W2123946088 @default.
- W1979858170 cites W2131684992 @default.
- W1979858170 cites W2132495676 @default.
- W1979858170 cites W2135943330 @default.
- W1979858170 cites W2161727276 @default.
- W1979858170 cites W2161789547 @default.
- W1979858170 cites W2163900487 @default.
- W1979858170 cites W2165274499 @default.
- W1979858170 cites W2169591849 @default.
- W1979858170 cites W2616834435 @default.
- W1979858170 doi "https://doi.org/10.4161/cc.10.20.17886" @default.
- W1979858170 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3356833" @default.
- W1979858170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22067655" @default.
- W1979858170 hasPublicationYear "2011" @default.
- W1979858170 type Work @default.
- W1979858170 sameAs 1979858170 @default.
- W1979858170 citedByCount "72" @default.
- W1979858170 countsByYear W19798581702012 @default.
- W1979858170 countsByYear W19798581702013 @default.
- W1979858170 countsByYear W19798581702014 @default.
- W1979858170 countsByYear W19798581702015 @default.
- W1979858170 countsByYear W19798581702016 @default.
- W1979858170 countsByYear W19798581702017 @default.
- W1979858170 countsByYear W19798581702018 @default.
- W1979858170 countsByYear W19798581702019 @default.
- W1979858170 countsByYear W19798581702020 @default.
- W1979858170 countsByYear W19798581702021 @default.
- W1979858170 countsByYear W19798581702022 @default.
- W1979858170 countsByYear W19798581702023 @default.
- W1979858170 crossrefType "journal-article" @default.
- W1979858170 hasAuthorship W1979858170A5017460289 @default.
- W1979858170 hasAuthorship W1979858170A5033235128 @default.
- W1979858170 hasAuthorship W1979858170A5055882378 @default.
- W1979858170 hasAuthorship W1979858170A5068371835 @default.
- W1979858170 hasAuthorship W1979858170A5074667950 @default.
- W1979858170 hasAuthorship W1979858170A5084058345 @default.
- W1979858170 hasBestOaLocation W19798581701 @default.
- W1979858170 hasConcept C104317684 @default.
- W1979858170 hasConcept C112446052 @default.
- W1979858170 hasConcept C11960822 @default.
- W1979858170 hasConcept C126322002 @default.
- W1979858170 hasConcept C127561419 @default.
- W1979858170 hasConcept C134018914 @default.
- W1979858170 hasConcept C2776780712 @default.
- W1979858170 hasConcept C2777391703 @default.
- W1979858170 hasConcept C2779306644 @default.
- W1979858170 hasConcept C2780124434 @default.
- W1979858170 hasConcept C43060935 @default.
- W1979858170 hasConcept C55493867 @default.
- W1979858170 hasConcept C62478195 @default.
- W1979858170 hasConcept C71924100 @default.
- W1979858170 hasConcept C86554907 @default.
- W1979858170 hasConcept C86803240 @default.
- W1979858170 hasConcept C95444343 @default.
- W1979858170 hasConcept C97029542 @default.