Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979858404> ?p ?o ?g. }
- W1979858404 endingPage "2105" @default.
- W1979858404 startingPage "2097" @default.
- W1979858404 abstract "1 Isoarecolone was approximately 250 times less potent than nicotine as an inhibitor of [3H]-nicotine binding to rat brain membranes. Isoarecolone failed to inhibit the binding of the nicotinic ligand [125I]-α-bungarotoxin or of the muscarinic ligand [3H]-QNB. 2 Nicotine (0.01–30 μm) evoked the release of [3H]-dopamine from striatal and frontal cortex synaptosomes, with EC50 values of approximately 0.5 μM in each case. This release was largely mecamylamine-sensitive. 3 Isoarecolone (1–200 μm) evoked predominantly mecamylamine-sensitive dopamine release from both striatal and cortical synaptosomes, with a potency at least 20 times less than that of nicotine. The maximum effect of isoarecolone was less than that of nicotine, particularly in the frontal cortex preparation. 4 In control rats treated chronically with saline, neither nicotine nor isoarecolone had clear effects on locomotor activity at the doses tested. Chronic treatment with nicotine clearly sensitized rats to the locomotor activating effect of nicotine; there was only weak cross-sensitization to isoarecolone. The maximum effect of isoarecolone was seen at a dose about 40 times larger than that of nicotine. 5 The low potency and efficacy of isoarecolone in facilitating sensitized locomotor activity resembled its lower potency and efficacy, compared with nicotine, in evoking dopamine release in vitro. The agonist profile of the nicotinic receptor population mediating dopamine release may determine the pharmacological characteristics of consequent locomotor behaviour." @default.
- W1979858404 created "2016-06-24" @default.
- W1979858404 creator A5020856949 @default.
- W1979858404 creator A5025249043 @default.
- W1979858404 creator A5027710789 @default.
- W1979858404 creator A5042951818 @default.
- W1979858404 date "1995-10-01" @default.
- W1979858404 modified "2023-10-14" @default.
- W1979858404 title "Locomotor activation and dopamine release produced by nicotine and isoarecolone in rats" @default.
- W1979858404 cites W1531560129 @default.
- W1979858404 cites W1981283169 @default.
- W1979858404 cites W1982037519 @default.
- W1979858404 cites W1986122184 @default.
- W1979858404 cites W1992031215 @default.
- W1979858404 cites W1992445358 @default.
- W1979858404 cites W1999762185 @default.
- W1979858404 cites W2001865657 @default.
- W1979858404 cites W2005274709 @default.
- W1979858404 cites W2011246896 @default.
- W1979858404 cites W2016148748 @default.
- W1979858404 cites W2019038288 @default.
- W1979858404 cites W2021193388 @default.
- W1979858404 cites W2021782736 @default.
- W1979858404 cites W2031647610 @default.
- W1979858404 cites W2033254523 @default.
- W1979858404 cites W2034172776 @default.
- W1979858404 cites W2038733942 @default.
- W1979858404 cites W2051591579 @default.
- W1979858404 cites W2054668681 @default.
- W1979858404 cites W2054683489 @default.
- W1979858404 cites W2061387768 @default.
- W1979858404 cites W2064409585 @default.
- W1979858404 cites W2070148261 @default.
- W1979858404 cites W2070493755 @default.
- W1979858404 cites W2070995312 @default.
- W1979858404 cites W2074184242 @default.
- W1979858404 cites W2074631079 @default.
- W1979858404 cites W2076818479 @default.
- W1979858404 cites W2079148999 @default.
- W1979858404 cites W2081532420 @default.
- W1979858404 cites W2081950565 @default.
- W1979858404 cites W2091951560 @default.
- W1979858404 cites W2092717777 @default.
- W1979858404 cites W2106071622 @default.
- W1979858404 cites W2106660639 @default.
- W1979858404 cites W2119530373 @default.
- W1979858404 cites W2226370386 @default.
- W1979858404 cites W4319293053 @default.
- W1979858404 doi "https://doi.org/10.1111/j.1476-5381.1995.tb16417.x" @default.
- W1979858404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1908939" @default.
- W1979858404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8640351" @default.
- W1979858404 hasPublicationYear "1995" @default.
- W1979858404 type Work @default.
- W1979858404 sameAs 1979858404 @default.
- W1979858404 citedByCount "65" @default.
- W1979858404 countsByYear W19798584042012 @default.
- W1979858404 countsByYear W19798584042013 @default.
- W1979858404 countsByYear W19798584042014 @default.
- W1979858404 countsByYear W19798584042015 @default.
- W1979858404 countsByYear W19798584042017 @default.
- W1979858404 countsByYear W19798584042018 @default.
- W1979858404 countsByYear W19798584042019 @default.
- W1979858404 countsByYear W19798584042020 @default.
- W1979858404 countsByYear W19798584042021 @default.
- W1979858404 countsByYear W19798584042022 @default.
- W1979858404 countsByYear W19798584042023 @default.
- W1979858404 crossrefType "journal-article" @default.
- W1979858404 hasAuthorship W1979858404A5020856949 @default.
- W1979858404 hasAuthorship W1979858404A5025249043 @default.
- W1979858404 hasAuthorship W1979858404A5027710789 @default.
- W1979858404 hasAuthorship W1979858404A5042951818 @default.
- W1979858404 hasBestOaLocation W19798584042 @default.
- W1979858404 hasConcept C126322002 @default.
- W1979858404 hasConcept C134018914 @default.
- W1979858404 hasConcept C170493617 @default.
- W1979858404 hasConcept C185592680 @default.
- W1979858404 hasConcept C188987157 @default.
- W1979858404 hasConcept C202751555 @default.
- W1979858404 hasConcept C2776880047 @default.
- W1979858404 hasConcept C2779547902 @default.
- W1979858404 hasConcept C2908647359 @default.
- W1979858404 hasConcept C513476851 @default.
- W1979858404 hasConcept C55493867 @default.
- W1979858404 hasConcept C57992300 @default.
- W1979858404 hasConcept C71924100 @default.
- W1979858404 hasConcept C98274493 @default.
- W1979858404 hasConcept C99454951 @default.
- W1979858404 hasConceptScore W1979858404C126322002 @default.
- W1979858404 hasConceptScore W1979858404C134018914 @default.
- W1979858404 hasConceptScore W1979858404C170493617 @default.
- W1979858404 hasConceptScore W1979858404C185592680 @default.
- W1979858404 hasConceptScore W1979858404C188987157 @default.
- W1979858404 hasConceptScore W1979858404C202751555 @default.
- W1979858404 hasConceptScore W1979858404C2776880047 @default.
- W1979858404 hasConceptScore W1979858404C2779547902 @default.
- W1979858404 hasConceptScore W1979858404C2908647359 @default.
- W1979858404 hasConceptScore W1979858404C513476851 @default.
- W1979858404 hasConceptScore W1979858404C55493867 @default.