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• W1979859079 startingPage "4308" @default.
• W1979859079 abstract "Traumatic spinal cord injury (SCI) results not only in motor impairment but also in chronic central pain, which can be refractory to conventional treatment approaches. It has been shown recently that in models of peripheral nerve injury, spinal cord microglia can become activated and contribute to development of pain. Considering their role in pain after peripheral injury, and because microglia are known to become activated after SCI, we tested the hypothesis that activated microglia contribute to chronic pain after SCI. In this study, adult male Sprague Dawley rats underwent T9 spinal cord contusion injury. Four weeks after injury, when lumbar dorsal horn multireceptive neurons became hyperresponsive and when behavioral nociceptive thresholds were decreased to both mechanical and thermal stimuli, intrathecal infusions of the microglial inhibitor minocycline were initiated. Electrophysiological experiments showed that minocycline rapidly attenuated hyperresponsiveness of lumbar dorsal horn neurons. Behavioral data showed that minocycline restored nociceptive thresholds, at which time spinal microglial cells assumed a quiescent morphological phenotype. Levels of phosphorylated-p38 were decreased in SCI animals receiving minocycline. Cessation of delivery of minocycline resulted in an immediate return of pain-related phenomena. These results suggest an important role for activated microglia in the maintenance of chronic central below-level pain after SCI and support the newly emerging role of non-neuronal immune cells as a contributing factor in post-SCI pain." @default.
• W1979859079 created "2016-06-24" @default.
• W1979859079 creator A5002957653 @default.
• W1979859079 creator A5003605658 @default.
• W1979859079 date "2006-04-19" @default.
• W1979859079 modified "2023-10-12" @default.
• W1979859079 title "Activated Microglia Contribute to the Maintenance of Chronic Pain after Spinal Cord Injury" @default.
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• W1979859079 doi "https://doi.org/10.1523/jneurosci.0003-06.2006" @default.
• W1979859079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6674010" @default.
• W1979859079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16624951" @default.
• W1979859079 hasPublicationYear "2006" @default.
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