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• W1979863898 abstract "to investigate health-related quality of life (HRQoL) in Italian patients with moderate and severe Crohn’s disease (CD) (Harvey Bradshaw Index>8). EuroQoL 5-dimension 3-level (EQ-5D-3L) questionnaire and visual analogue scale (VAS) were administered to 540 consecutive patients with moderate and severe CD who referred to a convenience sample of 38 Italian inflammatory bowel disease centres (21 teaching-hospitals; 4 research hospitals; 8 self-governing hospitals; 3 Local Health Authority hospitals; 2 private hospitals) participating in the ongoing Survey on Quality Of Life in Crohn’s Patients (SOLE) during 2012. As Italian EQ-5D-3L tariffs were not available at the time of the research, UK ones were used according to other comparable studies. Results concerning the first out of the 4 visits planned in SOLE study were reported as mean, standard deviation (SD), median and range. Correlation between EQ-5D-3L questionnaire and VAS scores was investigated via Kendall’s tau-b (Ktau-b). 531 patients (mean age: 41.3; SD: 13.8; median: 41; range: 18—84) responded to EQ-5D-3L questionnaire (98.3%) and 536 to VAS (99.6%). The most frequently marked levels for EQ-5D-3L questionnaire were: 1 for mobility (66.2%) and self-care (85.2%); 2 for usual activities (51.8%), pain/discomfort (70.7%), and anxiety/depression (53.4%). Overall scores for EQ-5D-3L questionnaire and VAS were 0.7 (SD: 0.3; median: 0.8; range: -0.2—1) and 54.3 (SD: 20.8; median: 55; range: 0—100), respectively. Six out of 531 EQ-5D-3L questionnaire responders (1.1%) valued their health state potentially worse than death (utility<0). VAS scores of 10 or multiple of 10 were marked by 298 out of 536 patients (55.6%). Ktau-b between EQ-5D-3L questionnaire and VAS scores reached 0.45 (p<0.001). No significant differences were detected when EQ-5D-3L questionnaire and VAS scores were stratified according to hospital institutional features. Italian patients with moderate and severe CD report a remarkable reduction in HRQoL." @default.
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• W1979863898 date "2014-11-01" @default.
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• W1979863898 title "Health-Related Quality of Life in Italian Patients With Moderate and Severe Crohn's Disease: Interim Results from the Sole Study" @default.
• W1979863898 doi "https://doi.org/10.1016/j.jval.2014.08.1908" @default.
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