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- W1979876693 abstract "Letters1 April 1980Side Effects of IbuprofenROBERT D. BRANDSTETTER, M.D., DEXTER D. MAR, PHARM. D.ROBERT D. BRANDSTETTER, M.D.Search for more papers by this author, DEXTER D. MAR, PHARM. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-4-569_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In his otherwise excellent review of ibuprofen (1), Dr. Kantor has omitted adverse renal side effects when he discusses this drug's adverse effects. Over the last 2 years, significant attention has been directed towards deterioration of renal function caused by nonsteroidal anti-inflammatory drugs, including ibuprofen (2-5). The mechanism of the renal dysfunction is believed to involve renal prostaglandin synthetase inhibition with resulting alteration in renal hemodynamics (2)....References1. KANTOR T. Ibuprofen. Ann Intern Med. 1979;91:877-82. LinkGoogle Scholar2. KIMBERLY R, BOWDEN R, KEISER H, and PLOTZ P. Reduction of renal function by newer nonsteroidal anti-inflammatory drugs. Am J Med. 1978;64:804-7. CrossrefMedlineGoogle Scholar3. BREZIN J, KATZ S, SCHWARTZ A, and CHINITZ J. Reversible renal failure and nephrotic syndrome associated with nonsteroidal anti-inflammatory drugs. N Engl J Med. 1979;301:1271-3. CrossrefMedlineGoogle Scholar4. BRANDSTETTER R and MAR D. Reversible oliguric renal failure associated with ibuprofen treatment. Br Med J. 1978;2:1194-5. CrossrefMedlineGoogle Scholar5. KIMBERLY R and BRANDSTETTER R. Exacerbation of phenylbutazone-related renal failure by indomethacin. Arch Intern Med. 1978;138:1711-2. CrossrefMedlineGoogle Scholar1. KANTOR T. Ibuprofen. Ann Intern Med. 1979;91:877-82. LinkGoogle Scholar2. STERNLIEB P and ROBINSON R. Stevens-Johnson syndrome plus toxic hepatitis due to ibuprofen. NY State J Med. 1978;78:1239-43. MedlineGoogle Scholar3. STEMPEL D and MILLER J. Lymphopenia and hepatic toxicity with ibuprofen. J Pediatr. 1977;90:657-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT D. BRANDSTETTER, M.D.; DEXTER D. MAR, PHARM. D.Affiliations: The New York Hospital-Cornell University Medical Center New York, NY 10021 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1980Volume 92, Issue 4Page: 569-570KeywordsAdverse reactionsDrugsHemodynamicsIbuprofenLigasesProstaglandin ePublished: 1 December 2008 Issue Published: 1 April 1980 PDF downloadLoading ..." @default.
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