Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979877215> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1979877215 endingPage "A19" @default.
- W1979877215 startingPage "A18" @default.
- W1979877215 abstract "<h3>Introduction</h3> An altered colonic microbiota contributes to inflammatory bowel disease (IBD) pathogenesis. Adult studies suggest modification of the microbiota by synbiotics (probiotics+prebiotics) can improve ulcerative colitis (UC)1 and Crohn9s disease (CD)2. <h3>Aim</h3> To assess the feasibility of using a synbiotic in children with IBD. <h3>Methods</h3> Patients with IBD aged 6 to 16 years were approached. Children were excluded if they used any prebiotic/probiotic agent in the preceding 14 days, were using antibiotics or had a severe IBD exacerbation. Patients were withdrawn if they started antibiotics or another prebiotic/probiotic or they wished to discontinue. Participation involved taking the probiotic (<i>Bifidobacterium longum</i> in a capsule) and prebiotic (3.5 g Synergy 1 inulin oligofructose) twice daily for 12 weeks. A pre-study questionnaire and physician9s global assessment (PGA) were completed. Questionnaires were provided for return at 1, 4, 8 and 12 weeks. Trial completion involved finishing the synbiotic course and returning all questionnaires. <h3>Results</h3> 23 children were recruited. 11 (48%) were male. Median age was 13.4 years (7.8–16.6 years). 11 had CD, 6 UC and 4 IBD-unspecified. Initial PGA was ‘inactive’ in 19, ‘mild’ in 3, ‘moderate’ in 1 and ‘severe’ in 1. Only 3 of the first 17 patients completed the study. Feedback indicated the prebiotic was poorly tolerated, therefore the last six participants undertook a tapered probiotic course: none in week 1, once daily in week 2, then twice daily from week 3. Only two of six completed the modified study. Completion overall was 5/23 (22%). Reasons for withdrawal were: six diarrhoea/IBD flare, six stopped returning questionnaires, four required antibiotics, one advised by GP because of rash, one unwell on prebiotic but completed probiotic and one parent stopped after noticing ‘no difference. <h3>Conclusion</h3> Although synbiotics have shown promise in adult IBD this feasibility study in fairly well paediatric IBD patients has shown poor tolerability. We suspect the drop-out rate was due to the prebiotic agent, but further studies are necessary to assess the tolerance of different prebiotics/probiotics in paediatric IBD before larger efficacy trials." @default.
- W1979877215 created "2016-06-24" @default.
- W1979877215 creator A5029540675 @default.
- W1979877215 creator A5036253048 @default.
- W1979877215 creator A5065487041 @default.
- W1979877215 creator A5069062337 @default.
- W1979877215 creator A5072224767 @default.
- W1979877215 creator A5082227457 @default.
- W1979877215 date "2011-04-01" @default.
- W1979877215 modified "2023-10-05" @default.
- W1979877215 title "Synbiotics for inflammatory bowel disease: useful in adults but problematic in paediatrics" @default.
- W1979877215 cites W1954857031 @default.
- W1979877215 cites W2131691027 @default.
- W1979877215 doi "https://doi.org/10.1136/adc.2011.212563.34" @default.
- W1979877215 hasPublicationYear "2011" @default.
- W1979877215 type Work @default.
- W1979877215 sameAs 1979877215 @default.
- W1979877215 citedByCount "5" @default.
- W1979877215 countsByYear W19798772152015 @default.
- W1979877215 countsByYear W19798772152020 @default.
- W1979877215 countsByYear W19798772152021 @default.
- W1979877215 countsByYear W19798772152022 @default.
- W1979877215 countsByYear W19798772152023 @default.
- W1979877215 crossrefType "journal-article" @default.
- W1979877215 hasAuthorship W1979877215A5029540675 @default.
- W1979877215 hasAuthorship W1979877215A5036253048 @default.
- W1979877215 hasAuthorship W1979877215A5065487041 @default.
- W1979877215 hasAuthorship W1979877215A5069062337 @default.
- W1979877215 hasAuthorship W1979877215A5072224767 @default.
- W1979877215 hasAuthorship W1979877215A5082227457 @default.
- W1979877215 hasConcept C100544194 @default.
- W1979877215 hasConcept C126322002 @default.
- W1979877215 hasConcept C185592680 @default.
- W1979877215 hasConcept C2775980262 @default.
- W1979877215 hasConcept C2776996202 @default.
- W1979877215 hasConcept C2777014857 @default.
- W1979877215 hasConcept C2778260677 @default.
- W1979877215 hasConcept C2779134260 @default.
- W1979877215 hasConcept C2779337445 @default.
- W1979877215 hasConcept C2780206646 @default.
- W1979877215 hasConcept C2780255968 @default.
- W1979877215 hasConcept C2780305828 @default.
- W1979877215 hasConcept C2780479503 @default.
- W1979877215 hasConcept C31903555 @default.
- W1979877215 hasConcept C501593827 @default.
- W1979877215 hasConcept C523546767 @default.
- W1979877215 hasConcept C54355233 @default.
- W1979877215 hasConcept C71924100 @default.
- W1979877215 hasConcept C86803240 @default.
- W1979877215 hasConcept C89423630 @default.
- W1979877215 hasConcept C90924648 @default.
- W1979877215 hasConceptScore W1979877215C100544194 @default.
- W1979877215 hasConceptScore W1979877215C126322002 @default.
- W1979877215 hasConceptScore W1979877215C185592680 @default.
- W1979877215 hasConceptScore W1979877215C2775980262 @default.
- W1979877215 hasConceptScore W1979877215C2776996202 @default.
- W1979877215 hasConceptScore W1979877215C2777014857 @default.
- W1979877215 hasConceptScore W1979877215C2778260677 @default.
- W1979877215 hasConceptScore W1979877215C2779134260 @default.
- W1979877215 hasConceptScore W1979877215C2779337445 @default.
- W1979877215 hasConceptScore W1979877215C2780206646 @default.
- W1979877215 hasConceptScore W1979877215C2780255968 @default.
- W1979877215 hasConceptScore W1979877215C2780305828 @default.
- W1979877215 hasConceptScore W1979877215C2780479503 @default.
- W1979877215 hasConceptScore W1979877215C31903555 @default.
- W1979877215 hasConceptScore W1979877215C501593827 @default.
- W1979877215 hasConceptScore W1979877215C523546767 @default.
- W1979877215 hasConceptScore W1979877215C54355233 @default.
- W1979877215 hasConceptScore W1979877215C71924100 @default.
- W1979877215 hasConceptScore W1979877215C86803240 @default.
- W1979877215 hasConceptScore W1979877215C89423630 @default.
- W1979877215 hasConceptScore W1979877215C90924648 @default.
- W1979877215 hasIssue "Supplement 1" @default.
- W1979877215 hasLocation W19798772151 @default.
- W1979877215 hasOpenAccess W1979877215 @default.
- W1979877215 hasPrimaryLocation W19798772151 @default.
- W1979877215 hasRelatedWork W1888609100 @default.
- W1979877215 hasRelatedWork W2030211067 @default.
- W1979877215 hasRelatedWork W2285885208 @default.
- W1979877215 hasRelatedWork W2745998491 @default.
- W1979877215 hasRelatedWork W2809784323 @default.
- W1979877215 hasRelatedWork W3138975441 @default.
- W1979877215 hasRelatedWork W3158094404 @default.
- W1979877215 hasRelatedWork W3195246536 @default.
- W1979877215 hasRelatedWork W4242733706 @default.
- W1979877215 hasRelatedWork W4311423189 @default.
- W1979877215 hasVolume "96" @default.
- W1979877215 isParatext "false" @default.
- W1979877215 isRetracted "false" @default.
- W1979877215 magId "1979877215" @default.
- W1979877215 workType "article" @default.