Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979882250> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1979882250 endingPage "1235" @default.
- W1979882250 startingPage "1230" @default.
- W1979882250 abstract "For poorly soluble weak bases, the possibility of drug precipitation upon entry into the small intestine may affect the amount of drug available for uptake through the intestinal mucosa. A few years ago, a transfer model was introduced which has been developed to simulate the transfer of a dissolved drug out of the stomach into the small intestine. However, this setup requires the use of clinically relevant doses of the drug, which are typically not available in the early stages of formulation development. The present series of tests was performed to check whether it is possible to create a miniaturized but physiologically relevant transfer model that can be applied in the early formulation development. Experiments were performed with two miniaturized setups: a 96-well plate model and a mini-paddle transfer system. Itraconazole and tamoxifen were used as model drugs. An appropriate amount of each drug formulation was dissolved in simulated gastric fluid and then transferred into an acceptor phase consisting of fasted/fed state simulated small intestinal fluid. The amount of drug dissolved in the acceptor phase was monitored over a period of 4 h. Results from both setups were very similar. The tamoxifen preformulation did not precipitate, whereas the itraconazole formulation precipitated to the same extent in both setups. Due to the possibility of generating physiologically relevant results but using smaller sample sizes and smaller volumes of media, both miniaturized transfer systems offer various advantages in terms of substance and analytical and material cost savings when evaluating the precipitation potential of poorly soluble weakly basic drug candidates." @default.
- W1979882250 created "2016-06-24" @default.
- W1979882250 creator A5010391424 @default.
- W1979882250 creator A5017897490 @default.
- W1979882250 creator A5037037002 @default.
- W1979882250 date "2012-09-12" @default.
- W1979882250 modified "2023-10-06" @default.
- W1979882250 title "Miniaturized Transfer Models to Predict the Precipitation of Poorly Soluble Weak Bases upon Entry into the Small Intestine" @default.
- W1979882250 cites W1672347066 @default.
- W1979882250 cites W1964575627 @default.
- W1979882250 cites W2008168342 @default.
- W1979882250 cites W2020446438 @default.
- W1979882250 cites W2052446737 @default.
- W1979882250 cites W2067115098 @default.
- W1979882250 cites W2069486893 @default.
- W1979882250 cites W2126241900 @default.
- W1979882250 cites W2161339650 @default.
- W1979882250 cites W2335729269 @default.
- W1979882250 doi "https://doi.org/10.1208/s12249-012-9851-y" @default.
- W1979882250 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3513478" @default.
- W1979882250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22968547" @default.
- W1979882250 hasPublicationYear "2012" @default.
- W1979882250 type Work @default.
- W1979882250 sameAs 1979882250 @default.
- W1979882250 citedByCount "20" @default.
- W1979882250 countsByYear W19798822502013 @default.
- W1979882250 countsByYear W19798822502014 @default.
- W1979882250 countsByYear W19798822502015 @default.
- W1979882250 countsByYear W19798822502016 @default.
- W1979882250 countsByYear W19798822502018 @default.
- W1979882250 countsByYear W19798822502019 @default.
- W1979882250 countsByYear W19798822502020 @default.
- W1979882250 countsByYear W19798822502021 @default.
- W1979882250 countsByYear W19798822502023 @default.
- W1979882250 crossrefType "journal-article" @default.
- W1979882250 hasAuthorship W1979882250A5010391424 @default.
- W1979882250 hasAuthorship W1979882250A5017897490 @default.
- W1979882250 hasAuthorship W1979882250A5037037002 @default.
- W1979882250 hasBestOaLocation W19798822502 @default.
- W1979882250 hasConcept C107054158 @default.
- W1979882250 hasConcept C121332964 @default.
- W1979882250 hasConcept C153294291 @default.
- W1979882250 hasConcept C178790620 @default.
- W1979882250 hasConcept C185592680 @default.
- W1979882250 hasConcept C186060115 @default.
- W1979882250 hasConcept C26873012 @default.
- W1979882250 hasConcept C2777882243 @default.
- W1979882250 hasConcept C2779892579 @default.
- W1979882250 hasConcept C43617362 @default.
- W1979882250 hasConcept C44280652 @default.
- W1979882250 hasConcept C55493867 @default.
- W1979882250 hasConcept C77281830 @default.
- W1979882250 hasConcept C86803240 @default.
- W1979882250 hasConceptScore W1979882250C107054158 @default.
- W1979882250 hasConceptScore W1979882250C121332964 @default.
- W1979882250 hasConceptScore W1979882250C153294291 @default.
- W1979882250 hasConceptScore W1979882250C178790620 @default.
- W1979882250 hasConceptScore W1979882250C185592680 @default.
- W1979882250 hasConceptScore W1979882250C186060115 @default.
- W1979882250 hasConceptScore W1979882250C26873012 @default.
- W1979882250 hasConceptScore W1979882250C2777882243 @default.
- W1979882250 hasConceptScore W1979882250C2779892579 @default.
- W1979882250 hasConceptScore W1979882250C43617362 @default.
- W1979882250 hasConceptScore W1979882250C44280652 @default.
- W1979882250 hasConceptScore W1979882250C55493867 @default.
- W1979882250 hasConceptScore W1979882250C77281830 @default.
- W1979882250 hasConceptScore W1979882250C86803240 @default.
- W1979882250 hasIssue "4" @default.
- W1979882250 hasLocation W19798822501 @default.
- W1979882250 hasLocation W19798822502 @default.
- W1979882250 hasLocation W19798822503 @default.
- W1979882250 hasLocation W19798822504 @default.
- W1979882250 hasOpenAccess W1979882250 @default.
- W1979882250 hasPrimaryLocation W19798822501 @default.
- W1979882250 hasRelatedWork W2001238053 @default.
- W1979882250 hasRelatedWork W2005582074 @default.
- W1979882250 hasRelatedWork W2073335704 @default.
- W1979882250 hasRelatedWork W2106796651 @default.
- W1979882250 hasRelatedWork W2152827663 @default.
- W1979882250 hasRelatedWork W2328664687 @default.
- W1979882250 hasRelatedWork W2338245430 @default.
- W1979882250 hasRelatedWork W2344892901 @default.
- W1979882250 hasRelatedWork W2421990564 @default.
- W1979882250 hasRelatedWork W69554321 @default.
- W1979882250 hasVolume "13" @default.
- W1979882250 isParatext "false" @default.
- W1979882250 isRetracted "false" @default.
- W1979882250 magId "1979882250" @default.
- W1979882250 workType "article" @default.