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• W1979883604 abstract "We tested whether exposure to anabolic-androgenic steroids (AASs) would induce apoptosis in adult rat ventricular myocytes in vitro. Myocytes were exposed to stanozolol (STZ), testosterone enanthate (TE) and testosterone (T) (0.1 μmol/L, 1 μmol/L, 10 μmol/L, and 100 μmol/L) for 20 h. The percentage of myocytes undergoing apoptosis was determined by terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL) and was found to be increased when compared to control myocytes at STZ 10 μmol/L 12 ± 2% (mean ± SD), STZ 100 μmol/L 42 ± 3%; TE 1 μmol/L 11 ± 2%, TE 10 μmol/L 21 ± 3%, TE 100 μmol/L 62 ± 2%; T 10 μmol/L 11 ± 2%, T 100 μmol/L 40 ± 3% (P < 0.001 vs. CTL 2 ± 2%). The STZ-, TE- and T-induced dose-dependent apoptotic cell death was corroborated by a significantly increased DNA laddering in myocytes exposed to STZ and T ≥ 10 μmol/L and TE ≥ 1 μmol/L. Notably, STZ, TE, and T exposure markedly increased the expression of the pro-apoptotic oncogene Bax-α, as assessed by reverse transcription-polymerase chain reaction. Taken together, these results clearly show for the first time that AASs induce apoptotic cell death in a dose-dependent manner. This finding may have important implications in understanding the pathogenesis of ventricular remodeling, cardiomyopathy, and sudden cardiac death associated with AAS abuse. © 2001 Wiley-Liss, Inc." @default.
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• W1979883604 date "2001-01-01" @default.
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• W1979883604 title "Anabolic-androgenic steroids induce apoptotic cell death in adult rat ventricular myocytes" @default.
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• W1979883604 doi "https://doi.org/10.1002/1097-4652(2001)9999:9999<00::aid-jcp1057>3.0.co;2-y" @default.
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