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• W1979883968 abstract "Synaptic communication requires precise alignment of presynaptic active zones with postsynaptic receptors to enable rapid and efficient neurotransmitter release. How transsynaptic signaling between connected partners organizes this synaptic apparatus is poorly understood. To further define the mechanisms that mediate synapse assembly, we carried out a chemical mutagenesis screen in Drosophila to identify mutants defective in the alignment of active zones with postsynaptic glutamate receptor fields at the larval neuromuscular junction. From this screen we identified a mutation in Actin 57B that disrupted synaptic morphology and presynaptic active zone organization. Actin 57B, one of six actin genes in Drosophila, is expressed within the postsynaptic bodywall musculature. The isolated allele, actE84K, harbors a point mutation in a highly conserved glutamate residue in subdomain 1 that binds members of the Calponin Homology protein family, including spectrin. Homozygous actE84K mutants show impaired alignment and spacing of presynaptic active zones, as well as defects in apposition of active zones to postsynaptic glutamate receptor fields. actE84K mutants have disrupted postsynaptic actin networks surrounding presynaptic boutons, with the formation of aberrant actin swirls previously observed following disruption of postsynaptic spectrin. Consistent with a disruption of the postsynaptic actin cytoskeleton, spectrin, adducin and the PSD-95 homolog Discs-Large are all mislocalized in actE84K mutants. Genetic interactions between actE84K and neurexin mutants suggest that the postsynaptic actin cytoskeleton may function together with the Neurexin–Neuroligin transsynaptic signaling complex to mediate normal synapse development and presynaptic active zone organization." @default.
• W1979883968 created "2016-06-24" @default.
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• W1979883968 date "2014-07-01" @default.
• W1979883968 modified "2023-09-24" @default.
• W1979883968 title "Postsynaptic actin regulates active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junction" @default.
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• W1979883968 doi "https://doi.org/10.1016/j.mcn.2014.07.005" @default.
• W1979883968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4134997" @default.
• W1979883968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25066865" @default.
• W1979883968 hasPublicationYear "2014" @default.
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