Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979887100> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W1979887100 endingPage "473a" @default.
- W1979887100 startingPage "473a" @default.
- W1979887100 abstract "Calcium plays a major role in controlling the opening and closing of the large conductance BKCa channels. Two high affinity binding sites have been identified in the channel structure and one of these sites is the DRDD loop in the N-terminus of the RCK1 domain. Mutation of the first aspartate in this conserved DRDD motif significantly reduces Ca2+ sensitivity and hence this residue has been implicated as a coordinating group in the binding site. Here we present results on the prediction of the Ca2+ binding site based on a series of detailed computational studies. The basic protocol involves multiple iterations of random ion placement, implicit solvent molecular dynamics simulations and statistical analysis. Our resulting model matches very well with existing mutagenesis data, and subsequent explicit solvent molecular dynamics simulations have been performed using this Ca2+ bound structure. Comparison of the dynamics and conformations of the Ca2+ bound and unbound simulations reveal a concerted conformational change in the structure and suggest a potential mechanism for calcium dependent activation of these channels." @default.
- W1979887100 created "2016-06-24" @default.
- W1979887100 creator A5023378358 @default.
- W1979887100 creator A5049386920 @default.
- W1979887100 creator A5055263040 @default.
- W1979887100 date "2009-02-01" @default.
- W1979887100 modified "2023-10-05" @default.
- W1979887100 title "Calcium Binding Causes A Conformational Change in The RCK1 Domain of The BK(Ca) Channel" @default.
- W1979887100 doi "https://doi.org/10.1016/j.bpj.2008.12.2450" @default.
- W1979887100 hasPublicationYear "2009" @default.
- W1979887100 type Work @default.
- W1979887100 sameAs 1979887100 @default.
- W1979887100 citedByCount "0" @default.
- W1979887100 crossrefType "journal-article" @default.
- W1979887100 hasAuthorship W1979887100A5023378358 @default.
- W1979887100 hasAuthorship W1979887100A5049386920 @default.
- W1979887100 hasAuthorship W1979887100A5055263040 @default.
- W1979887100 hasBestOaLocation W19798871001 @default.
- W1979887100 hasConcept C104317684 @default.
- W1979887100 hasConcept C107824862 @default.
- W1979887100 hasConcept C121332964 @default.
- W1979887100 hasConcept C121932024 @default.
- W1979887100 hasConcept C12554922 @default.
- W1979887100 hasConcept C147597530 @default.
- W1979887100 hasConcept C16318435 @default.
- W1979887100 hasConcept C178790620 @default.
- W1979887100 hasConcept C185592680 @default.
- W1979887100 hasConcept C26873012 @default.
- W1979887100 hasConcept C2777339483 @default.
- W1979887100 hasConcept C2781338088 @default.
- W1979887100 hasConcept C501734568 @default.
- W1979887100 hasConcept C519063684 @default.
- W1979887100 hasConcept C55493867 @default.
- W1979887100 hasConcept C59593255 @default.
- W1979887100 hasConcept C71240020 @default.
- W1979887100 hasConcept C8010536 @default.
- W1979887100 hasConcept C86803240 @default.
- W1979887100 hasConceptScore W1979887100C104317684 @default.
- W1979887100 hasConceptScore W1979887100C107824862 @default.
- W1979887100 hasConceptScore W1979887100C121332964 @default.
- W1979887100 hasConceptScore W1979887100C121932024 @default.
- W1979887100 hasConceptScore W1979887100C12554922 @default.
- W1979887100 hasConceptScore W1979887100C147597530 @default.
- W1979887100 hasConceptScore W1979887100C16318435 @default.
- W1979887100 hasConceptScore W1979887100C178790620 @default.
- W1979887100 hasConceptScore W1979887100C185592680 @default.
- W1979887100 hasConceptScore W1979887100C26873012 @default.
- W1979887100 hasConceptScore W1979887100C2777339483 @default.
- W1979887100 hasConceptScore W1979887100C2781338088 @default.
- W1979887100 hasConceptScore W1979887100C501734568 @default.
- W1979887100 hasConceptScore W1979887100C519063684 @default.
- W1979887100 hasConceptScore W1979887100C55493867 @default.
- W1979887100 hasConceptScore W1979887100C59593255 @default.
- W1979887100 hasConceptScore W1979887100C71240020 @default.
- W1979887100 hasConceptScore W1979887100C8010536 @default.
- W1979887100 hasConceptScore W1979887100C86803240 @default.
- W1979887100 hasIssue "3" @default.
- W1979887100 hasLocation W19798871001 @default.
- W1979887100 hasOpenAccess W1979887100 @default.
- W1979887100 hasPrimaryLocation W19798871001 @default.
- W1979887100 hasRelatedWork W1737694362 @default.
- W1979887100 hasRelatedWork W1774036674 @default.
- W1979887100 hasRelatedWork W1966666957 @default.
- W1979887100 hasRelatedWork W2007545289 @default.
- W1979887100 hasRelatedWork W2016433378 @default.
- W1979887100 hasRelatedWork W2058612844 @default.
- W1979887100 hasRelatedWork W2146991322 @default.
- W1979887100 hasRelatedWork W2351300819 @default.
- W1979887100 hasRelatedWork W2583629652 @default.
- W1979887100 hasRelatedWork W2899738154 @default.
- W1979887100 hasVolume "96" @default.
- W1979887100 isParatext "false" @default.
- W1979887100 isRetracted "false" @default.
- W1979887100 magId "1979887100" @default.
- W1979887100 workType "article" @default.