FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979892425> ?p ?o ?g. }

• W1979892425 endingPage "e40930" @default.
• W1979892425 startingPage "e40930" @default.
• W1979892425 abstract "There is accumulating evidence to implicate the importance of EphBs receptors and ephrinBs ligands were involved in modulation of spinal nociceptive information. However, the downstream mechanisms that control this process are not well understood. In the present study, we investigated whether phosphatidylinositol 3-kinase (PI3K), as the downstream effectors, participates in modulation of spinal nociceptive information related to ephrinBs/EphBs. Intrathecal injection of ephrinB1-Fc produced a dose- and time-dependent thermal and mechanical hyperalgesia, accompanied by the increase of spinal PI3K-p110γ, phosphorylation of AKT (p-AKT) and c-Fos expression. Pre-treatment with PI3K inhibitor wortmannin or LY294002 prevented activation of spinal AKT induced by ephrinB1-Fc. Inhibition of spinal PI3K signaling dose-dependently prevented and reversed pain behaviors and spinal c-Fos protein expression induced by intrathecal injection of ephrinB1-Fc. Inhibition of EphBs receptors by intrathecal injection of EphB1-Fc reduced formalin-induced inflammation and chronic constrictive injury-induced neuropathic pain behaviors accompanied by decreased expression of spinal PI3K,p-AKT and c-Fos protein. Furthermore, pre-treatment with PI3K inhibitor wortmannin or LY294002 prevented ephrinB1-Fc-induced ERK activation in spinal. These data demonstrated that PI3K and PI3K crosstalk to ERK signaling contributed to modulation of spinal nociceptive information related to ephrinBs/EphBs." @default.
• W1979892425 created "2016-06-24" @default.
• W1979892425 creator A5001934465 @default.
• W1979892425 creator A5004000135 @default.
• W1979892425 creator A5012845876 @default.
• W1979892425 creator A5036215524 @default.
• W1979892425 creator A5056780474 @default.
• W1979892425 creator A5064960317 @default.
• W1979892425 creator A5071001810 @default.
• W1979892425 creator A5080928792 @default.
• W1979892425 date "2012-08-03" @default.
• W1979892425 modified "2023-10-14" @default.
• W1979892425 title "PI3K Contributed to Modulation of Spinal Nociceptive Information Related to ephrinBs/EphBs" @default.
• W1979892425 cites W1688463639 @default.
• W1979892425 cites W1971927237 @default.
• W1979892425 cites W1975858506 @default.
• W1979892425 cites W1977219612 @default.
• W1979892425 cites W1978771622 @default.
• W1979892425 cites W1979675387 @default.
• W1979892425 cites W1983704814 @default.
• W1979892425 cites W1984836191 @default.
• W1979892425 cites W1992187858 @default.
• W1979892425 cites W1994979780 @default.
• W1979892425 cites W2004518871 @default.
• W1979892425 cites W2008796590 @default.
• W1979892425 cites W2013492510 @default.
• W1979892425 cites W2014007136 @default.
• W1979892425 cites W2015676327 @default.
• W1979892425 cites W2017537032 @default.
• W1979892425 cites W2027998355 @default.
• W1979892425 cites W2028930604 @default.
• W1979892425 cites W2034102455 @default.
• W1979892425 cites W2038400469 @default.
• W1979892425 cites W2039784545 @default.
• W1979892425 cites W2042113277 @default.
• W1979892425 cites W2042410160 @default.
• W1979892425 cites W2045694820 @default.
• W1979892425 cites W2046822015 @default.
• W1979892425 cites W2050696396 @default.
• W1979892425 cites W2051405592 @default.
• W1979892425 cites W2058020736 @default.
• W1979892425 cites W2060638940 @default.
• W1979892425 cites W2060798263 @default.
• W1979892425 cites W2061159466 @default.
• W1979892425 cites W2062408585 @default.
• W1979892425 cites W2066442640 @default.
• W1979892425 cites W2068225015 @default.
• W1979892425 cites W2068915942 @default.
• W1979892425 cites W2069918422 @default.
• W1979892425 cites W2069941772 @default.
• W1979892425 cites W2073541816 @default.
• W1979892425 cites W2075204586 @default.
• W1979892425 cites W2079650065 @default.
• W1979892425 cites W2086003460 @default.
• W1979892425 cites W2086692188 @default.
• W1979892425 cites W2093117697 @default.
• W1979892425 cites W2093842873 @default.
• W1979892425 cites W2106449226 @default.
• W1979892425 cites W2111514922 @default.
• W1979892425 cites W2122778405 @default.
• W1979892425 cites W2128635872 @default.
• W1979892425 cites W2130283578 @default.
• W1979892425 cites W2137979524 @default.
• W1979892425 cites W2144168839 @default.
• W1979892425 cites W2148134111 @default.
• W1979892425 cites W2165066750 @default.
• W1979892425 cites W2316620113 @default.
• W1979892425 cites W2417170318 @default.
• W1979892425 doi "https://doi.org/10.1371/journal.pone.0040930" @default.
• W1979892425 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3411731" @default.
• W1979892425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22879882" @default.
• W1979892425 hasPublicationYear "2012" @default.
• W1979892425 type Work @default.
• W1979892425 sameAs 1979892425 @default.
• W1979892425 citedByCount "43" @default.
• W1979892425 countsByYear W19798924252014 @default.
• W1979892425 countsByYear W19798924252015 @default.
• W1979892425 countsByYear W19798924252016 @default.
• W1979892425 countsByYear W19798924252017 @default.
• W1979892425 countsByYear W19798924252018 @default.
• W1979892425 countsByYear W19798924252019 @default.
• W1979892425 countsByYear W19798924252020 @default.
• W1979892425 countsByYear W19798924252022 @default.
• W1979892425 countsByYear W19798924252023 @default.
• W1979892425 crossrefType "journal-article" @default.
• W1979892425 hasAuthorship W1979892425A5001934465 @default.
• W1979892425 hasAuthorship W1979892425A5004000135 @default.
• W1979892425 hasAuthorship W1979892425A5012845876 @default.
• W1979892425 hasAuthorship W1979892425A5036215524 @default.
• W1979892425 hasAuthorship W1979892425A5056780474 @default.
• W1979892425 hasAuthorship W1979892425A5064960317 @default.
• W1979892425 hasAuthorship W1979892425A5071001810 @default.
• W1979892425 hasAuthorship W1979892425A5080928792 @default.
• W1979892425 hasBestOaLocation W19798924251 @default.
• W1979892425 hasConcept C126322002 @default.
• W1979892425 hasConcept C15490471 @default.
• W1979892425 hasConcept C169760540 @default.
• W1979892425 hasConcept C170493617 @default.

• next