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W1979895989 abstract "The antimalarial activity of a series of 4-anilinoquinolines was modeled with topological and other functional descriptors using feature selection approaches CP-MLR and GA. Five models were identified from each approach to explain the activity of the compounds. They jointly shared eighteen descriptors. Among them five descriptors, namely, H-052, MATS4m, MATS7e, Mor30p, and R7m, were common to both approaches. In PLS analysis the eighteen descriptors have led to a three-component model (<svg style=vertical-align:-0.1638pt;width:69.5625px; id=M1 height=16.049999 version=1.1 viewBox=0 0 69.5625 16.049999 width=69.5625 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,15.775)><path id=x1D45F d=M393 379q-9 -16 -28 -29q-15 -10 -23 -2q-19 19 -36 19q-21 0 -52 -38q-57 -72 -82 -126l-40 -197q-23 -3 -75 -18l-7 7q49 196 74 335q7 43 -2 43q-7 0 -30 -14.5t-47 -37.5l-16 23q37 42 82 73t67 31q41 0 15 -113l-11 -50h4q41 71 85 117t77 46q29 0 45 -26
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W1979895989 date "2013-01-01" @default.
W1979895989 modified "2023-09-23" @default.
W1979895989 title "Topological Features in Profiling the Antimalarial Activity Landscape of Anilinoquinolines: A Multipronged QSAR Study" @default.
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