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- W1979899469 abstract "Abstract Tracheal organ cultures metabolized a mixture of benzo(a)pyrene quinones (BP-quinones) into products which were not extracted with acetone/ethyl acetate and were water-soluble. When the culture medium was extracted of the organic soluble metabolites and the water-soluble metabolites exposed to β-glucuronidase, BP-quinones and an unidentified highly polar metabolite was released. When the results were evaluated quantitatively it was found that 30% of the water-soluble metabolites were glucuronide conjugates. The remaining 70% of the aqueous soluble radioactivity was not sensitive to β-glucuronidase and was not identified. When BP was used as the substrate in tracheal organ culture, treatment of the aqueous soluble metabolites with β-glucuronidase resulted in the release of some BP-quinones. It has previously been assumed that BP-quinones are “end-products” of BP metabolism, however, this report clearly demonstrates that BP-quinones are subject to further metabolic processes." @default.
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- W1979899469 date "1979-08-01" @default.
- W1979899469 modified "2023-09-23" @default.
- W1979899469 title "Benzo(a)pyrene quinone metabolism in tracheal organ cultures" @default.
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- W1979899469 doi "https://doi.org/10.1016/0006-291x(79)91861-8" @default.
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