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- W1979903669 abstract "Abstract In the dog hypophysectomy caused a fall and close arterial infusion of ACTH resulted in a rise in the pregnenolone content of the adrenal gland. A study of the distribution of steroids in subcellular fractions of the dog adrenal gland showed that the largest total quantities (and concentrations per mg protein) were present in the mitochondria. The mitochondrial pregnenolone content was increased by ACTH. These findings do not support the hypothesis that end product inhibition by pregnenolone of its synthesis from cholesterol in the mitochondria plays a key role in the regulation of adrenal steroid synthesis." @default.
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- W1979903669 date "1975-09-01" @default.
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- W1979903669 title "Effect of ACTH on the total pregnenolone content of the adrenal gland and its subcellular distribution" @default.
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- W1979903669 doi "https://doi.org/10.1016/0022-4731(75)90356-8" @default.
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