FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979907880> ?p ?o ?g. }

• W1979907880 endingPage "4913" @default.
• W1979907880 startingPage "4905" @default.
• W1979907880 abstract "Cordycepin (3′-deoxyadenosine) is an adenosine analogue isolated from Cordyceps sinensis, which is a Chinese herbal medicine known to have many benefits, including adjustment of the physical condition, an anticancer effect, and enhancement of sexual performance. It was previously demonstrated that cordycepin could simultaneously activate steroidogenesis and apoptosis in MA-10 mouse Leydig tumor cells. However, the mechanism remains elusive. Thus, aim of the present study was to investigate the steroidogenic and apoptotic mechanism of cordycepin in MA-10 cells. MA-10 cells were treated with cordycepin at various dosages and time courses plus different protein kinase inhibitors. Steroid production, protein expression, and cell viability were then determined. Results illustrated that cordycepin stimulated MA-10 cell steroidogenesis in dose- and time-dependent relationships. However, cordycepin could not induce steroidogenic acute regulatory (StAR) protein expression. However, cordycepin did activate the phospholipase C/protein kinase C (PLC/PKC), but not PKA and PI3K, pathway to induce MA-10 cell steroidogenesis. Moreover, cordycepin could stimulate the phosphorylation of PKC, extracellular signal-regulated kinase 1/2 (ERK1/2), and c-Jun N-terminal kinase (c-JNK), but not p38, in MA-10 cells. In addition, cordycepin could activate the PKC pathway to induce MA-10 cell death, and this death effect was not caused by cordycepin-stimulated progesterone from MA-10 cells. In conclusion, cordycepin stimulated intracellular PLC/PKC and MAPK signal transduction pathways to induce steroidogenesis and cell death in MA-10 mouse Leydig tumor cells." @default.
• W1979907880 created "2016-06-24" @default.
• W1979907880 creator A5026443765 @default.
• W1979907880 creator A5061253670 @default.
• W1979907880 creator A5072728629 @default.
• W1979907880 creator A5089582123 @default.
• W1979907880 date "2012-05-01" @default.
• W1979907880 modified "2023-10-16" @default.
• W1979907880 title "Cordycepin Stimulated Steroidogenesis in MA-10 Mouse Leydig Tumor Cells through the Protein Kinase C Pathway" @default.
• W1979907880 cites W1599163395 @default.
• W1979907880 cites W1967432915 @default.
• W1979907880 cites W1967842367 @default.
• W1979907880 cites W1972961427 @default.
• W1979907880 cites W1980242952 @default.
• W1979907880 cites W1982169641 @default.
• W1979907880 cites W1982836618 @default.
• W1979907880 cites W1989254646 @default.
• W1979907880 cites W1994065128 @default.
• W1979907880 cites W2000609399 @default.
• W1979907880 cites W2001293789 @default.
• W1979907880 cites W2024307572 @default.
• W1979907880 cites W2029781499 @default.
• W1979907880 cites W2038453942 @default.
• W1979907880 cites W2041432911 @default.
• W1979907880 cites W2042052859 @default.
• W1979907880 cites W2050228751 @default.
• W1979907880 cites W2050476941 @default.
• W1979907880 cites W2051708236 @default.
• W1979907880 cites W2057316408 @default.
• W1979907880 cites W2057446599 @default.
• W1979907880 cites W2064979570 @default.
• W1979907880 cites W2087590552 @default.
• W1979907880 cites W2093957373 @default.
• W1979907880 cites W2105054937 @default.
• W1979907880 cites W2112187558 @default.
• W1979907880 cites W2114070261 @default.
• W1979907880 cites W2121743546 @default.
• W1979907880 cites W2134555179 @default.
• W1979907880 cites W2168818408 @default.
• W1979907880 doi "https://doi.org/10.1021/jf205091b" @default.
• W1979907880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22512531" @default.
• W1979907880 hasPublicationYear "2012" @default.
• W1979907880 type Work @default.
• W1979907880 sameAs 1979907880 @default.
• W1979907880 citedByCount "54" @default.
• W1979907880 countsByYear W19799078802012 @default.
• W1979907880 countsByYear W19799078802013 @default.
• W1979907880 countsByYear W19799078802014 @default.
• W1979907880 countsByYear W19799078802015 @default.
• W1979907880 countsByYear W19799078802016 @default.
• W1979907880 countsByYear W19799078802017 @default.
• W1979907880 countsByYear W19799078802018 @default.
• W1979907880 countsByYear W19799078802019 @default.
• W1979907880 countsByYear W19799078802020 @default.
• W1979907880 countsByYear W19799078802021 @default.
• W1979907880 countsByYear W19799078802022 @default.
• W1979907880 countsByYear W19799078802023 @default.
• W1979907880 crossrefType "journal-article" @default.
• W1979907880 hasAuthorship W1979907880A5026443765 @default.
• W1979907880 hasAuthorship W1979907880A5061253670 @default.
• W1979907880 hasAuthorship W1979907880A5072728629 @default.
• W1979907880 hasAuthorship W1979907880A5089582123 @default.
• W1979907880 hasConcept C184235292 @default.
• W1979907880 hasConcept C190283241 @default.
• W1979907880 hasConcept C195794163 @default.
• W1979907880 hasConcept C2780066241 @default.
• W1979907880 hasConcept C51551487 @default.
• W1979907880 hasConcept C55493867 @default.
• W1979907880 hasConcept C57074206 @default.
• W1979907880 hasConcept C62478195 @default.
• W1979907880 hasConcept C86803240 @default.
• W1979907880 hasConcept C95444343 @default.
• W1979907880 hasConcept C97029542 @default.
• W1979907880 hasConceptScore W1979907880C184235292 @default.
• W1979907880 hasConceptScore W1979907880C190283241 @default.
• W1979907880 hasConceptScore W1979907880C195794163 @default.
• W1979907880 hasConceptScore W1979907880C2780066241 @default.
• W1979907880 hasConceptScore W1979907880C51551487 @default.
• W1979907880 hasConceptScore W1979907880C55493867 @default.
• W1979907880 hasConceptScore W1979907880C57074206 @default.
• W1979907880 hasConceptScore W1979907880C62478195 @default.
• W1979907880 hasConceptScore W1979907880C86803240 @default.
• W1979907880 hasConceptScore W1979907880C95444343 @default.
• W1979907880 hasConceptScore W1979907880C97029542 @default.
• W1979907880 hasIssue "19" @default.
• W1979907880 hasLocation W19799078801 @default.
• W1979907880 hasLocation W19799078802 @default.
• W1979907880 hasOpenAccess W1979907880 @default.
• W1979907880 hasPrimaryLocation W19799078801 @default.
• W1979907880 hasRelatedWork W1976734851 @default.
• W1979907880 hasRelatedWork W2004726042 @default.
• W1979907880 hasRelatedWork W2005481865 @default.
• W1979907880 hasRelatedWork W2013052548 @default.
• W1979907880 hasRelatedWork W205417214 @default.
• W1979907880 hasRelatedWork W2070643674 @default.
• W1979907880 hasRelatedWork W2419118008 @default.
• W1979907880 hasRelatedWork W3035328115 @default.
• W1979907880 hasRelatedWork W3141260101 @default.

• next