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- W1979919605 abstract "Abstract Aminophylline is a 2:1 mixture of theophylline and ethylenediamine which is widely used as a bronchorelaxant for the treatment of asthma. More recently, it has been claimed that formulations of aminophylline in topical creams are useful for the reduction of lower body fat. As part of a study of the efficacy of such formulations, we have developed a chromatographic method for the analysis of aminophylline in cream preparations. The method involves dissolving the creams in an acetone-water solvent, derivatizing the aminophylline components with dansyl chloride and analyzing the resulting mixtures by reversed-phase high performance liquid chromatography (HPLC). Because other components of the creams are separated from the aminophylline components during the HPLC analysis, no extractions of aminophylline from the creams are required. However, vigorous stirring of the reaction mixture during the dansylation is required to ensure that all of the aminophylline components are derivatized. Several commercial aminophylline-based thigh cream formulations were analyzed by this method. It was found that these formulations varied significantly in the amount of aminophylline present." @default.
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- W1979919605 date "1997-09-01" @default.
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- W1979919605 title "Analysis of Aminophylline in Thigh Cream Formulations by High Performance Liquid Chromatography" @default.
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- W1979919605 doi "https://doi.org/10.1080/10826079708002711" @default.
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