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- W1979928539 abstract "The use of rituximab-based chemoimmunotherapy regimens has dramatically improved the overall survival of patients with non-Hodgkin’s lymphomas (NHLs), across all categories. However, relapse and resistance to rituximab frequently hampers the possibility of a cure, and the development of more and more effective therapeutic strategies represents an urgent medical need for lymphoma patients. Importantly, the management of indolent lymphomas still remains a clinical challenge, with no curative treatments available. Despite the lack of common-shared tumor-restricted “druggable” antigens for B-cell lymphoma, exciting progress has been made toward the characterization of the molecular mechanisms sustaining the growth of these diseases. A broad array of novel compounds interfering with prolymphoma signaling pathways are now available, and most of them have already demonstrated a clear evidence of activity against NHL. In the near future, it is highly likely that the introduction of these agents in polychemoimmunotherapy programs will increase the therapeutic windows of these regimens toward more specific and effective antitumor activity with reduced toxicity. Furthermore, increasing evidences are showing the critical role of microenvironment, and in particular immune cells, for B-cell lymphoma survival and proliferation. The possibility of counteracting the immunosuppressant tumor niche through the effective recruitment of a continuing antitumor immune attack is an attractive therapeutic option. The development of immunomodulatory drugs, the recent demonstration that certain conventional chemotherapeutic agents can provide immune-adjuvant side effects, and the continuous advancement in active immunotherapeutic strategies thus open new possibilities for the design of rationale chemoimmunotherapy combination strategies for maximal antilymphoma cytotoxic and immune effects." @default.
- W1979928539 created "2016-06-24" @default.
- W1979928539 creator A5066576514 @default.
- W1979928539 creator A5069425402 @default.
- W1979928539 date "2012-01-01" @default.
- W1979928539 modified "2023-09-23" @default.
- W1979928539 title "Non-Hodgkin’s Lymphomas" @default.
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