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- W1979933686 abstract "The cDNA sequences encoding the mesotocin receptor (MTR) and vasotocin 1a receptor (VTR-1a) were identified in a urodele amphibian, the rough-skinned newt, Taricha granulosa. Saturation binding of [(3)H]oxytocin (OT) to the Taricha MTR (tMTR) was best fit by a two-state model; a high affinity-low abundance site and a lower affinity-high abundance site. Competition-binding studies found the following rank-order affinities for the tMTR: mesotocin (MT)>OT≈vasotocin (VT)>vasopressin (VP)>isotocin (IT). Inositol phosphate (IP) accumulation studies demonstrated functional activity of both the tMTR and Taricha VTR-1a (tVTR-1a) in a heterologous cell culture system. The rank-order potencies for the tMTR were MT>OT>VT≈VP>IT. The combined binding and IP results indicate that VT may act as a partial agonist of the tMTR. Rank-order potencies for the tVTR-1a were VT>VP>MT≈OT>IT. For both receptors, stimulation of IP accumulation was blocked by d(CH(2))(5)[Tyr(Me)(2)]AVP (Manning compound) and d(CH(2))(5)[Tyr(Me)(2),Thr(4),Tyr-NH(2)]OVT (OTA). OTA was a more potent antagonist for the transiently expressed tMTR while Manning compound was relatively more potent at inhibiting IP accumulation in tVTR-1a expressing cells. In contradiction to earlier assumptions, the absolute IC(50) of Manning compound was lower for the tMTR (27nM±13) than the tVTR-1a (586nM±166) indicating its potential higher affinity for the tMTR, a finding with special relevance to interpretation of comparative studies investigating the behavioral and physiological actions of neurohypophysial peptides in non-mammalian species." @default.
- W1979933686 created "2016-06-24" @default.
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- W1979933686 date "2011-01-01" @default.
- W1979933686 modified "2023-10-10" @default.
- W1979933686 title "Identification and characterization of mesotocin and V1a-like vasotocin receptors in a urodele amphibian, Taricha granulosa" @default.
- W1979933686 cites W1163995844 @default.
- W1979933686 cites W132077006 @default.
- W1979933686 cites W1513763742 @default.
- W1979933686 cites W1543985160 @default.
- W1979933686 cites W1549512600 @default.
- W1979933686 cites W1947762817 @default.
- W1979933686 cites W1964645539 @default.
- W1979933686 cites W1964862071 @default.
- W1979933686 cites W1967403408 @default.
- W1979933686 cites W1967945214 @default.
- W1979933686 cites W1975485923 @default.
- W1979933686 cites W1975731777 @default.
- W1979933686 cites W1987867902 @default.
- W1979933686 cites W1992213589 @default.
- W1979933686 cites W1996996770 @default.
- W1979933686 cites W2002855569 @default.
- W1979933686 cites W2002948635 @default.
- W1979933686 cites W2005490081 @default.
- W1979933686 cites W2006327345 @default.
- W1979933686 cites W2007060613 @default.
- W1979933686 cites W2008911868 @default.
- W1979933686 cites W2009200322 @default.
- W1979933686 cites W2012885311 @default.
- W1979933686 cites W2014612381 @default.
- W1979933686 cites W2015303493 @default.
- W1979933686 cites W2018862358 @default.
- W1979933686 cites W2020828649 @default.
- W1979933686 cites W2023890730 @default.
- W1979933686 cites W2028458405 @default.
- W1979933686 cites W2033852503 @default.
- W1979933686 cites W2034866241 @default.
- W1979933686 cites W2035451604 @default.
- W1979933686 cites W2036454147 @default.
- W1979933686 cites W2037364012 @default.
- W1979933686 cites W2038689340 @default.
- W1979933686 cites W2041863961 @default.
- W1979933686 cites W2043337264 @default.
- W1979933686 cites W2044878407 @default.
- W1979933686 cites W2045295426 @default.
- W1979933686 cites W2045483781 @default.
- W1979933686 cites W2055896822 @default.
- W1979933686 cites W2059491555 @default.
- W1979933686 cites W2062583603 @default.
- W1979933686 cites W2065403108 @default.
- W1979933686 cites W2066700253 @default.
- W1979933686 cites W2070471019 @default.
- W1979933686 cites W2070821979 @default.
- W1979933686 cites W2072353408 @default.
- W1979933686 cites W2076729451 @default.
- W1979933686 cites W2081823965 @default.
- W1979933686 cites W2082215793 @default.
- W1979933686 cites W2083325896 @default.
- W1979933686 cites W2086090539 @default.
- W1979933686 cites W2086590061 @default.
- W1979933686 cites W2089445595 @default.
- W1979933686 cites W2092050340 @default.
- W1979933686 cites W2094056766 @default.
- W1979933686 cites W2097382368 @default.
- W1979933686 cites W2099487632 @default.
- W1979933686 cites W2100492328 @default.
- W1979933686 cites W2101713116 @default.
- W1979933686 cites W2103184061 @default.
- W1979933686 cites W2105264030 @default.
- W1979933686 cites W2107872320 @default.
- W1979933686 cites W2110745698 @default.
- W1979933686 cites W2111184181 @default.
- W1979933686 cites W2131706912 @default.
- W1979933686 cites W2132036505 @default.
- W1979933686 cites W2134771022 @default.
- W1979933686 cites W2139129258 @default.
- W1979933686 cites W2139770620 @default.
- W1979933686 cites W2139786039 @default.
- W1979933686 cites W2144401070 @default.
- W1979933686 cites W2151463677 @default.
- W1979933686 cites W2154905333 @default.
- W1979933686 cites W2156243671 @default.
- W1979933686 cites W2159860239 @default.
- W1979933686 cites W2168558973 @default.
- W1979933686 cites W2174465159 @default.
- W1979933686 cites W2743744776 @default.
- W1979933686 cites W4239787582 @default.
- W1979933686 cites W4245831452 @default.
- W1979933686 cites W4254983016 @default.
- W1979933686 doi "https://doi.org/10.1016/j.ygcen.2010.09.017" @default.
- W1979933686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20920503" @default.
- W1979933686 hasPublicationYear "2011" @default.
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