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- W1979936616 abstract "Fragile X syndrome (FXS) is a common form of mental disability characterized by hypersensitivity to sensory stimuli, hyperactivity and severe cognitive impairment. FXS is caused by loss of the fragile X mental retardation 1 ( FMR1 ) gene, whose fragile X mental retardation protein (FMRP) regulates mRNA translation downstream of synaptic activity to modulate changes in synaptic architecture, function and plasticity. FXS is one of the known causes of autism and there is no effective treatment that corrects the deficit in FMRP. However, new advances in the knowledge of the molecular pathophysiology of FXS have opened different strategies for the future development of effective drugs. Among the emerging targets are several protein kinases, neuronal calcium sensors, muscarinic receptors, potassium channels, endocannabinoid system, etc. Moreover, some small molecules such statins, antioxidants, glycogen synthase kinase 3 inhibitors among others have showed an improved in cognition and behavioral tests in FXS mouse model emerging as promising drug candidates for FXS pharmacological treatment in the next future." @default.
- W1979936616 created "2016-06-24" @default.
- W1979936616 creator A5007294350 @default.
- W1979936616 creator A5028669057 @default.
- W1979936616 creator A5034309855 @default.
- W1979936616 creator A5060896107 @default.
- W1979936616 date "2015-08-01" @default.
- W1979936616 modified "2023-09-26" @default.
- W1979936616 title "Therapeutic approaches for the future treatment of Fragile X" @default.
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