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- W1979950406 abstract "The reported cases of severe, isolated congenital factor VII deficiency are reviewed and compared with the present studies. In all, fifty-two cases fulfill the necessary diagnostic criteria. The deficiency appears to be due to a “defective” autosomal gene, full clinical expression of hemorrhagic symptoms appearing only in the homozygous subject. The decay of transfused factor VII has two components, with respective half-lives of 35 and 300 minutes. Treatment of factor VII-deficient patients with plasma or plasma extracts is effective in controlling all types of spontaneous hemorrhage and in preventing hemorrhage associated with major surgical procedures. A successful course of longterm prophylactic plasma therapy is described." @default.
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- W1979950406 date "1964-08-01" @default.
- W1979950406 modified "2023-09-27" @default.
- W1979950406 title "Clinical aspects of congenital factor VII deficiency" @default.
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- W1979950406 doi "https://doi.org/10.1016/0002-9343(64)90004-x" @default.
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