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- W1979957400 endingPage "603" @default.
- W1979957400 startingPage "592" @default.
- W1979957400 abstract "Normal cellular function is maintained by coordinated proteome machinery that performs a vast array of activities. Helping the proteome in such roles is the chaperome, a network of molecular chaperones and folding enzymes. The stressed cell contains, at any time, a complex mixture of chaperome complexes; a majority performs 'housekeeping functions' similarly to non-stressed, normal cells, but a finely-tuned fraction buffers the proteome altered by chronic stress. The stress chaperome is epigenetically distinct from its normal, housekeeping counterpart, providing a basis for its selective targeting by small molecules. We discuss here the development of chaperome inhibitors, and how agents targeting chaperome members in stressed cells are in fact being directed towards chaperome complexes, and their effect is therefore determined by their ability to sample and engage such complexes. A new approach is needed to target and implement chaperome modulators in the investigation of diseases, and we propose that the classical thinking in drug discovery needs adjustment when developing chaperome-targeting drugs." @default.
- W1979957400 created "2016-06-24" @default.
- W1979957400 creator A5036001871 @default.
- W1979957400 creator A5040925962 @default.
- W1979957400 creator A5051009059 @default.
- W1979957400 creator A5054531681 @default.
- W1979957400 date "2014-11-01" @default.
- W1979957400 modified "2023-09-30" @default.
- W1979957400 title "Selective targeting of the stress chaperome as a therapeutic strategy" @default.
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