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- W1979960571 abstract "Objective: To assess the incidence and binding sites of antisperm antibodies in patients following vasectomy reversal by means of vasovasostomy (VV) and vasoepididymostomy (VE). Additionally, to assess differences in antisperm antibody characteristics between the two procedures. Design: Retrospective review of patients who underwent vasectomy reversal and routine post-operative antibody screening. Materials/Methods: Post-procedure semen specimens were screened for IgG and IgA antibodies via the Sperm-Mar™ (Fertipro NV, Belgium). The percentage of antibody-bound sperm and the antibody localization was recorded. The test was considered positive if <20% of the sperm were antibody bound. Results: Fifty patients completed antibody screening. Of these, 32 (64%) had a positive test. Seventeen (34%) were IgA-positive and 30 (60%) were IgG-positive. In the VE subgroup (n=10), 30% and 60% were positive for IgA and IgG, respectively. In the VV group (n=40), these incidences were 35% and 60%. Of the VE population no subject with a positive IgA test and only 1/5 (20%) with a positive IgG test exhibited head binding in >20% of the sperm. Of the VV group, 31% of those positive for IgA, and 63% of those positive for IgG had significant head binding (>20%). Conclusions: Antisperm antibodies are present in 64% of men following vasectomy reversal. There was no difference in the incidence of antibodies between VV and VE patients, indicating that both procedures are associated with a similar risk of immunological infertility. VV patients had a trend for higher levels of head binding, although the significance of this finding is unclear. The high incidence of antibodies in this screened population suggests that the discrepancy between technical success from a reversal procedure and successful pregnancy is due to immunological causes. Supported by: None." @default.
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- W1979960571 date "2002-09-01" @default.
- W1979960571 modified "2023-09-30" @default.
- W1979960571 title "Antisperm antibodies following vasovasostomy and vasoepididymostomy" @default.
- W1979960571 doi "https://doi.org/10.1016/s0015-0282(02)04101-8" @default.
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