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- W1979969446 abstract "Pulmonary arterial hypertension (PAH) is a rare but devastating disease that affects the pulmonary vasculature. It causes progressive right ventricular dysfunction and leads to worsening breathlessness, impaired quality of life and premature death. This article explores the role of the erectile dysfunction drug sildenafil in the treatment of PAH. The article discusses how, through its action on the phosphodiesterase-5 enzyme, sildenafil may help reverse vascular remodelling and cause selective vasodilatation of the pulmonary arteries, with little effect on the systemic circulation. Important adverse effects and potential serious drug interactions are also highlighted to help ensure the safe use of sildenafil in clinical practice." @default.
- W1979969446 created "2016-06-24" @default.
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- W1979969446 date "2007-02-01" @default.
- W1979969446 modified "2023-09-24" @default.
- W1979969446 title "Sildenafil: A recent advance in the treatment of pulmonary arterial hypertension" @default.
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- W1979969446 doi "https://doi.org/10.12968/bjca.2007.2.2.23051" @default.
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