FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979999423> ?p ?o ?g. }

• W1979999423 endingPage "568" @default.
• W1979999423 startingPage "565" @default.
• W1979999423 abstract "Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by the abnormal expansion of a polyglutamine tract in the huntingtin protein. We have developed PC12 cell lines in which the expression of an N-terminal truncation of huntingtin (N63) with either wild type (23Q) or expanded polyglutamine (148Q) can be induced by the removal of doxycycline. Differentiated PC12 cells induced to express N63-148Q showed cellular toxicity reaching up to 50% at 6 days post-induction. Histone acetyltransferase (HAT) activity and global histone acetylation was significantly decreased in cells expressing truncated huntingtin with mutant but not normal huntingtin. These data suggest that altered chromatin modification via reduction in coactivator activity may cause neuronal transcriptional dysregulation and contribute to cellular toxicity." @default.
• W1979999423 created "2016-06-24" @default.
• W1979999423 creator A5009145312 @default.
• W1979999423 creator A5028593542 @default.
• W1979999423 creator A5046079661 @default.
• W1979999423 creator A5047419065 @default.
• W1979999423 creator A5047629088 @default.
• W1979999423 creator A5058702148 @default.
• W1979999423 creator A5060850766 @default.
• W1979999423 creator A5069018183 @default.
• W1979999423 creator A5070611644 @default.
• W1979999423 creator A5072055814 @default.
• W1979999423 date "2003-03-01" @default.
• W1979999423 modified "2023-10-17" @default.
• W1979999423 title "Inducible PC12 cell model of Huntington’s disease shows toxicity and decreased histone acetylation" @default.
• W1979999423 cites W1532930401 @default.
• W1979999423 cites W1578515047 @default.
• W1979999423 cites W1855026199 @default.
• W1979999423 cites W1977383752 @default.
• W1979999423 cites W1993691393 @default.
• W1979999423 cites W2024472839 @default.
• W1979999423 cites W2034861130 @default.
• W1979999423 cites W2040506727 @default.
• W1979999423 cites W2043888873 @default.
• W1979999423 cites W2091989472 @default.
• W1979999423 cites W2099685145 @default.
• W1979999423 cites W2099997349 @default.
• W1979999423 cites W2104912043 @default.
• W1979999423 cites W2122440289 @default.
• W1979999423 cites W2132357350 @default.
• W1979999423 cites W2136364567 @default.
• W1979999423 cites W2140795771 @default.
• W1979999423 cites W2148688106 @default.
• W1979999423 cites W2149110755 @default.
• W1979999423 cites W2157513658 @default.
• W1979999423 cites W2332414364 @default.
• W1979999423 doi "https://doi.org/10.1097/00001756-200303240-00007" @default.
• W1979999423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12657886" @default.
• W1979999423 hasPublicationYear "2003" @default.
• W1979999423 type Work @default.
• W1979999423 sameAs 1979999423 @default.
• W1979999423 citedByCount "69" @default.
• W1979999423 countsByYear W19799994232012 @default.
• W1979999423 countsByYear W19799994232013 @default.
• W1979999423 countsByYear W19799994232014 @default.
• W1979999423 countsByYear W19799994232015 @default.
• W1979999423 countsByYear W19799994232016 @default.
• W1979999423 countsByYear W19799994232017 @default.
• W1979999423 countsByYear W19799994232018 @default.
• W1979999423 countsByYear W19799994232019 @default.
• W1979999423 countsByYear W19799994232020 @default.
• W1979999423 countsByYear W19799994232022 @default.
• W1979999423 crossrefType "journal-article" @default.
• W1979999423 hasAuthorship W1979999423A5009145312 @default.
• W1979999423 hasAuthorship W1979999423A5028593542 @default.
• W1979999423 hasAuthorship W1979999423A5046079661 @default.
• W1979999423 hasAuthorship W1979999423A5047419065 @default.
• W1979999423 hasAuthorship W1979999423A5047629088 @default.
• W1979999423 hasAuthorship W1979999423A5058702148 @default.
• W1979999423 hasAuthorship W1979999423A5060850766 @default.
• W1979999423 hasAuthorship W1979999423A5069018183 @default.
• W1979999423 hasAuthorship W1979999423A5070611644 @default.
• W1979999423 hasAuthorship W1979999423A5072055814 @default.
• W1979999423 hasConcept C104317684 @default.
• W1979999423 hasConcept C119157956 @default.
• W1979999423 hasConcept C126322002 @default.
• W1979999423 hasConcept C143065580 @default.
• W1979999423 hasConcept C153911025 @default.
• W1979999423 hasConcept C166252455 @default.
• W1979999423 hasConcept C180754005 @default.
• W1979999423 hasConcept C2776925932 @default.
• W1979999423 hasConcept C2777616661 @default.
• W1979999423 hasConcept C2778001298 @default.
• W1979999423 hasConcept C2779134260 @default.
• W1979999423 hasConcept C2779649592 @default.
• W1979999423 hasConcept C2780647506 @default.
• W1979999423 hasConcept C2781427258 @default.
• W1979999423 hasConcept C2910011555 @default.
• W1979999423 hasConcept C54355233 @default.
• W1979999423 hasConcept C64927066 @default.
• W1979999423 hasConcept C71924100 @default.
• W1979999423 hasConcept C83640560 @default.
• W1979999423 hasConcept C86803240 @default.
• W1979999423 hasConcept C95444343 @default.
• W1979999423 hasConceptScore W1979999423C104317684 @default.
• W1979999423 hasConceptScore W1979999423C119157956 @default.
• W1979999423 hasConceptScore W1979999423C126322002 @default.
• W1979999423 hasConceptScore W1979999423C143065580 @default.
• W1979999423 hasConceptScore W1979999423C153911025 @default.
• W1979999423 hasConceptScore W1979999423C166252455 @default.
• W1979999423 hasConceptScore W1979999423C180754005 @default.
• W1979999423 hasConceptScore W1979999423C2776925932 @default.
• W1979999423 hasConceptScore W1979999423C2777616661 @default.
• W1979999423 hasConceptScore W1979999423C2778001298 @default.
• W1979999423 hasConceptScore W1979999423C2779134260 @default.
• W1979999423 hasConceptScore W1979999423C2779649592 @default.
• W1979999423 hasConceptScore W1979999423C2780647506 @default.
• W1979999423 hasConceptScore W1979999423C2781427258 @default.

• next