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• W1980007945 abstract "The CBP [CREB (cAMP-response-element-binding protein)-binding protein]/p300 acetyltransferases function as transcriptional co-activators and play critical roles in cell differentiation and proliferation. Accumulating evidence shows that alterations of the CBP/p300 protein levels are linked to human tumours. In the present study, we show that the levels of the CBP/p300 co-activators are decreased dramatically by continuous PDGF (platelet-derived growth factor) and Ras signalling pathway activation in NIH 3T3 fibroblasts. This effect occurs by reducing the expression levels of the CBP/p300 genes. In addition, CBP and p300 are degraded by the 26 S proteasome pathway leading to an overall decrease in the levels of the CBP/p300 proteins. Furthermore, we provide evidence that Mdm2 (murine double minute 2), in the presence of active H-Ras or N-Ras, induces CBP/p300 degradation in NIH 3T3 cells. These findings support a novel mechanism for modulating other signalling transduction pathways that require these common co-activators." @default.
• W1980007945 created "2016-06-24" @default.
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• W1980007945 date "2006-08-15" @default.
• W1980007945 modified "2023-09-30" @default.
• W1980007945 title "The histone acetyltransferases CBP/p300 are degraded in NIH 3T3 cells by activation of Ras signalling pathway" @default.
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• W1980007945 doi "https://doi.org/10.1042/bj20060052" @default.
• W1980007945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1550303" @default.
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• W1980007945 hasPublicationYear "2006" @default.
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